Vesicular glutamate transporters 1 and 2 target to functionally distinct synaptic release sites

被引：388

作者：

Fremeau, RT

Kam, K

Qureshi, T

Johnson, J

Copenhagen, DR

Storm-Mathisen, J

Chaudhry, FA

Nicoll, RA

Edwards, RH ^{[1
]}

机构：

[1] Univ Calif San Francisco, Sch Med, Dept Physiol, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Sch Med, Dept Neurol, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Sch Med, Dept Cellular & Mol Pharmacol, San Francisco, CA 94143 USA

[4] Univ Calif San Francisco, Sch Med, Dept Ophthalmol, Grad Program Neurosci, San Francisco, CA 94143 USA

[5] Univ Calif San Francisco, Sch Med, Dept Ophthalmol, Grad Program Cell Biol, San Francisco, CA 94143 USA

[6] Univ Oslo, Inst Anat, N-0317 Oslo, Norway

[7] Univ Oslo, Ctr Mol Biol & Neurosci, N-0317 Oslo, Norway

来源：

SCIENCE | 2004年 / 304卷 / 5678期

关键词：

D O I：

10.1126/science.1097468

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Vesicular glutamate transporters (VGLUTs) 1 and 2 show a mutually exclusive distribution in the adult brain that suggests specialization for synapses with different properties of release. Consistent with this distribution, inactivation of the VGLUT1 gene silenced a subset of excitatory neurons in the adult. However, the same cell populations exhibited VGLUT1-independent transmission early in life. Developing hippocampal neurons transiently coexpressed VGLUT2 and VGLUT1 at distinct synaptic sites with different short-term plasticity. The loss of VGLUT1 also reduced the reserve pool of synaptic vesicles. Thus, VGLUT1 plays an unanticipated role in membrane trafficking at the nerve terminal.

引用

页码：1815 / 1819

页数：5

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