Bone tissue engineering: Hope vs hype

被引：405

作者：

Rose, FRAJ

Oreffo, ROC

机构：

[1] Univ Southampton, Gen Hosp, Southampton SO16 6YD, Hants, England

[2] Univ Nottingham, Sch Pharmaceut Sci, Nottingham NG7 2RD, England

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2002年 / 292卷 / 01期

基金：

英国生物技术与生命科学研究理事会; 英国工程与自然科学研究理事会;

关键词：

osteoprogenitor; bone marrow; bio-degradable polymer; tissue engineering; scaffold; artificial bone; bone regeneration; stem cell;

D O I：

10.1006/bbrc.2002.6519

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The requirement for new bone to replace or restore the function of traumatised, damaged, or lost bone is a major clinical and socioeconomic need. Bone formation strategies, although attractive, have yet to yield functional and mechanically competent bone. Bone tissue engineering has been heralded as the alternative strategy to regenerate bone. In essence, the discipline aims to combine progenitor or mature cells with biocompatible materials or scaffolds, with or without appropriate growth factors, to initiate repair and regeneration. This brief review outlines the concepts, challenges, and limitations in bone tissue engineering and the potential that could improve the quality of life for many as a result of interdisciplinary collaboration. (C) 2002 Elsevier Science (USA).

引用

页码：1 / 7

页数：7

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[52] Adenovirus-mediated direct gene therapy with bone morphogenetic protein-2 produces bone [J].