Control of immunoglobulin gene rearrangements in developing B cells

被引:32
作者
Papavasiliou, F
Jankovic, M
Gong, SC
Nussenzweig, MC
机构
[1] The Lab. of Molecular Immunology, Howard Hughes Med. Inst., R., New York
关键词
D O I
10.1016/S0952-7915(97)80141-0
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The antigen receptor on B lymphocytes is the product of a series of gene rearrangements which ends when a functional receptor gene is assembled. Recent work has shown that the receptor-associated molecules Ig alpha and Ig beta provide the signals that lead to inhibition of further recombination. Furthermore, Ig beta has been implicated in initiating the last step of the recombination reaction.
引用
收藏
页码:233 / 238
页数:6
相关论文
共 63 条
  • [1] ORDERED REARRANGEMENT OF IMMUNOGLOBULIN HEAVY-CHAIN VARIABLE REGION SEGMENTS
    ALT, FW
    YANCOPOULOS, GD
    BLACKWELL, TK
    WOOD, C
    THOMAS, E
    BOSS, M
    COFFMAN, R
    ROSENBERG, N
    TONEGAWA, S
    BALTIMORE, D
    [J]. EMBO JOURNAL, 1984, 3 (06) : 1209 - 1219
  • [2] Mechanism of V(D)J recombination
    Bogue, M
    Roth, DB
    [J]. CURRENT OPINION IN IMMUNOLOGY, 1996, 8 (02) : 175 - 180
  • [3] BURNET FM, 1959, CLONAL SELECTION THE
  • [4] PROTEIN TYROSINE PHOSPHORYLATION IN INDUCED IN MURINE LYMPHOCYTES-B IN RESPONSE TO STIMULATION WITH ANTIIMMUNOGLOBULIN
    CAMPBELL, MA
    SEFTON, BM
    [J]. EMBO JOURNAL, 1990, 9 (07) : 2125 - 2131
  • [5] SYK TYROSINE KINASE REQUIRED FOR MOUSE VIABILITY AND B-CELL DEVELOPMENT
    CHENG, AM
    ROWLEY, B
    PAO, W
    HAYDAY, A
    BOLEN, JB
    PAWSON, T
    [J]. NATURE, 1995, 378 (6554) : 303 - 306
  • [6] THE B-CELL ANTIGEN RECEPTOR COMPLEX - ASSOCIATION OF IG-ALPHA AND IG-BETA WITH DISTINCT CYTOPLASMIC EFFECTORS
    CLARK, MR
    CAMPBELL, KS
    KAZLAUSKAS, A
    JOHNSON, SA
    HERTZ, M
    POTTER, TA
    PLEIMAN, C
    CAMBIER, JC
    [J]. SCIENCE, 1992, 258 (5079) : 123 - 126
  • [7] PRE-B-CELL DEVELOPMENT IN THE ABSENCE OF LAMBDA-5 IN TRANSGENIC MICE EXPRESSING A HEAVY-CHAIN DISEASE PROTEIN
    CORCOS, D
    DUNDA, O
    BUTOR, C
    CESBRON, JY
    LORES, P
    BUCCHINI, D
    JAMI, J
    [J]. CURRENT BIOLOGY, 1995, 5 (10) : 1140 - 1148
  • [8] CHROMOSOMAL POSITION OF REARRANGING GENE SEGMENTS INFLUENCES ALLELIC EXCLUSION IN TRANSGENIC MICE
    COSTA, TEF
    SUH, H
    NUSSENZWEIG, MC
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (06) : 2205 - 2208
  • [9] ANALYSIS OF THE B-CELL PROGENITOR COMPARTMENT AT THE LEVEL OF SINGLE CELLS
    EHLICH, A
    MARTIN, V
    MULLER, W
    RAJEWSKY, K
    [J]. CURRENT BIOLOGY, 1994, 4 (07) : 573 - 583
  • [10] IMMUNOGLOBULIN HEAVY AND LIGHT CHAIN GENES REARRANGE INDEPENDENTLY AT EARLY STAGES OF B-CELL DEVELOPMENT
    EHLICH, A
    SCHAAL, S
    GU, H
    KITAMURA, D
    MULLER, W
    RAJEWSKY, K
    [J]. CELL, 1993, 72 (05) : 695 - 704