Retinoid metabolism: a balancing act

被引：35

作者：

Perlmann, T ^{[1
]}

机构：

[1] Karolinska Inst, Ludwig Inst Canc Res, S-17177 Stockholm, Sweden

来源：

NATURE GENETICS | 2002年 / 31卷 / 01期

关键词：

D O I：

10.1038/ng877

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The recent characterization of the aldehyde dehydrogenase Aldh1a2 and the cytochrome P450 Cyp26, two enzymes involved in retinoid metabolism, has helped to explain how bioactive retinoids are made and catabolized. By the elegant definition of an Aldh1a2 null mutation as a dominant suppressor of a Cyp26 null mutation, it is now unequivocally demonstrated that the main function of Cyp26 is to degrade endogenous all-trans retinoic acid rather than to synthesize bioactive hydroxylated retinoids.

引用

页码：7 / 8

页数：2

共 15 条

[1] The retinoic acid-metabolizing enzyme, CYP26A1, is essential for normal hindbrain patterning, vertebral identity, and development of posterior structures [J].

Abu-Abed, S ;

Dollé, P ;

Metzger, D ;

Beckett, B ;

Chambon, P ;

Petkovich, M .

GENES & DEVELOPMENT, 2001, 15 (02) :226-240

[2] INTRACELLULAR SIGNALING BY 14-HYDROXY-4,14-RETRO-RETINOL [J].

BUCK, J ;

DERGUINI, F ;

LEVI, E ;

NAKANISHI, K ;

HAMMERLING, U .

SCIENCE, 1991, 254 (5038) :1654-1656

[3] Families of retinoid dehydrogenases regulating vitamin A function - Production of visual pigment and retinoic acid [J].

Duester, G .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 2000, 267 (14) :4315-4324

[4] Metabolic inactivation of retinoic acid by a novel P450 differentially expressed in developing mouse embryos [J].

Fujii, H ;

Sato, T ;

Kaneko, S ;

Gotoh, O ;

FujiiKuriyama, Y ;

Osawa, K ;

Kato, S ;

Hamada, H .

EMBO JOURNAL, 1997, 16 (14) :4163-4173

[5] ENDOGENOUS DISTRIBUTION OF RETINOIDS DURING NORMAL DEVELOPMENT AND TERATOGENESIS IN THE MOUSE EMBRYO [J].

HORTON, C ;

MADEN, M .

DEVELOPMENTAL DYNAMICS, 1995, 202 (03) :312-323

[6]

Imam A, 2001, FASEB J, V15, P28

[7] Genetic evidence that oxidative derivatives of retinoic acid are not involved in retinoid signaling during mouse development [J].

Niederreither, K ;

Abu-Abed, S ;

Schuhbaur, B ;

Petkovich, M ;

Chambon, P ;

Dollé, P .

NATURE GENETICS, 2002, 31 (01) :84-88

[8] Embryonic retinoic acid synthesis is essential for early mouse post-implantation development [J].

Niederreither, K ;

Subbarayan, V ;

Dollé, P ;

Chambon, P .

NATURE GENETICS, 1999, 21 (04) :444-448

[9] THE RETINOID LIGAND 4-OXO-RETINOIC ACID IS A HIGHLY-ACTIVE MODULATOR OF POSITIONAL SPECIFICATION [J].

PIJNAPPEL, WWM ;

HENDRIKS, HFJ ;

FOLKERS, GE ;

VANDENBRINK, CE ;

DEKKER, EJ ;

EDELENBOSCH, C ;

VANDERSAAG, PT ;

DURSTON, AJ .

NATURE, 1993, 366 (6453) :340-344

[10] The retinoic acid-inactivating enzyme CYP26 is essential for establishing an uneven distribution of retinoic acid along the anterio-posterior axis within the mouse embryo [J].

Sakai, Y ;

Meno, C ;

Fujii, H ;

Nishino, J ;

Shiratori, H ;

Saijoh, Y ;

Rossant, J ;

Hamada, H .

GENES & DEVELOPMENT, 2001, 15 (02) :213-225

← 1 2 →