New enone derivatives of oleanolic acid and ursolic acid as inhibitors of nitric oxide production in mouse macrophages

被引:92
作者
Honda, T
Finlay, HJ
Gribble, GW
Suh, N
Sporn, MB
机构
[1] DARTMOUTH COLL,HITCHCOCK MED CTR,DARTMOUTH MED SCH,DEPT PHARMACOL & TOXICOL,HANOVER,NH 03755
[2] DARTMOUTH COLL,DEPT CHEM,HANOVER,NH 03755
关键词
D O I
10.1016/S0960-894X(97)00279-5
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
New derivatives of 3-oxoolean-1-en-28 oic acid and 3-oxours-1-en-28-oic acid were synthesized. Nine of them showed significant inhibitory activity against interferon-gamma-induced nitric oxide production in mouse macrophages when assayed at the 1 mu M level. 3,12-Dioxoolean-1,9-dien-28-oic acid (3) had the highest activity (IC50, 0.9 mu M). (C) 1997 Elsevier Science Ltd.
引用
收藏
页码:1623 / 1628
页数:6
相关论文
共 24 条
  • [21] SIMONSEN J, 1957, TERPENES, V5, P221
  • [22] Tang W., 1992, CHINESE DRUGS PLANT
  • [23] STUDIES ON DIFFERENTIATION-INDUCING ACTIVITIES OF TRITERPENES
    UMEHARA, K
    TAKAGI, R
    KUROYANAGI, M
    UENO, A
    TAKI, T
    CHEN, YJ
    [J]. CHEMICAL & PHARMACEUTICAL BULLETIN, 1992, 40 (02) : 401 - 405
  • [24] POTENT ANTITUMORIGENIC EFFECT OF TUBEIMOSIDE-1 ISOLATED FROM THE BULB OF BOLBOSTEMMA-PANICULATUM (MAXIM) FRANQUET
    YU, LJ
    MA, RD
    WANG, YQ
    NISHINO, H
    TAKAYASU, J
    HE, WZ
    CHANG, M
    ZHEN, J
    LIU, WS
    FAN, SX
    [J]. INTERNATIONAL JOURNAL OF CANCER, 1992, 50 (04) : 635 - 638