Synthesized different derivatives of low molecular fucoidan extracted from Laminaria japonica and their potential antioxidant activity in vitro

被引：82

作者：

Wang, Jing ^{[1
,2
]}

Wang, Feng ^{[3
]}

Zhang, Quanbin ^{[1
]}

Zhang, Zhongshan ^{[1
,2
]}

Shi, Xuelian ^{[1
,2
]}

Li, Pengcheng ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China

[3] Wei Fang Med Univ, Pharmaceut Lab, Weifang 261053, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2009年 / 44卷 / 05期

关键词：

Low molecular fucoidan; Derivatives; Antioxidant activity; RADICAL SCAVENGING ACTIVITY; ULVA-PERTUSA CHLOROPHYTA; SULFATED POLYSACCHARIDE; BENZOYLATED DERIVATIVES; GRIFOLA-FRONDOSA; CELLS;

D O I：

10.1016/j.ijbiomac.2009.02.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Six low molecular fucoidan (DFPS) derivatives were synthesized successfully, and their potential antioxidant activities were investigated employing various established in vitro systems. All DFPS derivatives possessed considerable antioxidant activity, and had stronger antioxidant ability than DFPS in certain tests. The benzoylated DFPS (PHDF) showed strongest scavenging activity on superoxide, hydroxyl and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, however, DFPS exhibited greatest reducing power. Available data suggested that substituted groups of DFPS played an important role on antioxidant activity, and the mechanism on influence the antioxidant activity of samples of substituted group was indicated. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：379 / 384

页数：6

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