Intestinal inflammation and pain management

被引：19

作者：

Basso, Lilian ^{[1
,2
,3
]}

Bourreille, Arnaud ^{[4
,5
]}

Dietrich, Gilles ^{[1
,2
,3
]}

机构：

[1] INSERM, U1043, F-31300 Toulouse, France

[2] CNRS, U5282, F-31300 Toulouse, France

[3] Univ Toulouse, UPS, F-31300 Toulouse, France

[4] INSERM, U913, F-44093 Nantes, France

[5] Univ Nantes, Inst Malad Appareil Digestif, F-44093 Nantes, France

来源：

CURRENT OPINION IN PHARMACOLOGY | 2015年 / 25卷

关键词：

RECEPTOR BLOCKADE INCREASES; T-CELL RESPONSE; CROHNS-DISEASE; HUMAN OPIORPHIN; VISCERAL PAIN; ENDOGENOUS REGULATION; BOWEL-DISEASE; TH17; CELLS; EXPRESSION; OPIOIDS;

D O I：

10.1016/j.coph.2015.11.004

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Intestinal inflammation results in the production of inflammatory pain-inducing mediators that may directly activate colon sensory neurons. Endogenous opioids produced by mucosa! effector CD4(+) T lymphocytes identified as colitogenic may paradoxically counterbalance the local proalgesic effect of inflammatory mediators by acting on opioid receptors expressed on sensory nerve endings. The review will focus on the endogenous immune-mediated regulation of visceral inflammatory pain, current pain treatments in inflammatory bowel diseases and prospectives on new opioid therapeutic opportunities to alleviate pain but avoiding common centrally-mediated side effects.

引用

页码：50 / 55

页数：6

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