Preparation and characterization of chitosan-poly(acrylic acid) polymer magnetic microspheres

被引：141

作者：

Wu, Yan ^{[1
]}

Guo, Jia ^{[1
]}

Yang, Wuli ^{[1
]}

Wang, Changchun ^{[1
]}

Fu, Shoukuan ^{[1
]}

机构：

[1] Fudan Univ, Key Lab Macromol Engn Polymers, Minist Educ, Dept Macromol Sci, Shanghai 200433, Peoples R China

来源：

POLYMER | 2006年 / 47卷 / 15期

基金：

中国国家自然科学基金;

关键词：

chitosan-poly(acrylic acid); polymer magnetic microspheres; controlled drug delivery;

D O I：

10.1016/j.polymer.2006.05.017

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A modified method to prepare chitosan-poly(acrylic acid)(CS-PAA) polymer magnetic microspheres was reported in this paper. First, via self-assembly of positively charged CS and negatively charged Fe3O4 nanoparticles, magnetic CS cores with a large amount of Fe3O4 nanoparticles were successfully prepared. Subsequently, the AA monomers were polymerized on the magetic CS cores based on the reaction system of water-soluble polymer-monomer pairs. These polymer magnetic microspheres had a high Fe3O4 loading content, and showed unique pH-dependent behaviors on the size and zeta potential. From the magnetometer measurements data, the CS-PAA polymer magnetic microspheres also had superparamagnetic property as well as fast magnetic response. A continuous release of the entrapped ammonium glycyrrhizinate in such polymer magnetic microspheres occurred, which confirmed the potential applications of these microspheres for the targeted delivery of drugs. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：5287 / 5294

页数：8

共 28 条

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