First total synthesis of (+)-viroallosecurinine

被引：54

作者：

Honda, T ^{[1
]}

Namiki, H ^{[1
]}

Watanabe, M ^{[1
]}

Mizutani, H ^{[1
]}

机构：

[1] Hoshi Univ, Fac Pharmaceut Sci, Shinagawa Ku, Tokyo 1428501, Japan

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 27期

关键词：

(+)-viroallosecurinine; ring closing-metathesis; chelation controlled addition; Securinega alkaloid; diastereoselective total synthesis;

D O I：

10.1016/j.tetlet.2004.05.031

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first diastereoselective chiral synthesis of (+)-viroallosecurinine, isolated front Securinega virosa as a cytotoxic alkaloid, was achieved by using a chelation-controlled addition of an alkyne moiety to the corresponding ketone, and a ring-metathesis, as key reactions. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：5211 / 5213

页数：3

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