Wound Edge Microvascular Blood Flow Effects of Negative Pressure Wound Therapy Using Gauze or Polyurethane Foam

被引：61

作者：

Malmsjo, Malin ^{[1
]}

Ingemansson, Richard ^{[2
]}

Martin, Robin ^{[3
]}

Huddleston, Elizabeth ^{[4
]}

机构：

[1] Univ Lund Hosp, Dept Ophthalmol, S-22185 Lund, Sweden

[2] Univ Lund Hosp, Dept Cardiothorac Surg, S-22185 Lund, Sweden

[3] Smith & Nephew Med Ltd, NPWT Strateg Business Unit, Kingston Upon Hull, N Humberside, England

[4] Smith & Nephew Med Ltd, Emerging Business Grp, Kingston Upon Hull, N Humberside, England

来源：

ANNALS OF PLASTIC SURGERY | 2009年 / 63卷 / 06期

关键词：

blood flow; microvasculature; negative pressure wound therapy; wound filler; VACUUM-ASSISTED CLOSURE; PERISTERNAL THORACIC WALL;

D O I：

10.1097/SAP.0b013e31819ae01b

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

The aim of this study was to examine the effects of negative pressure wound therapy (NPWT) on wound edge microvascular blood flow, comparing different wound fillers. Wounds were created on the backs of 7 pigs. NPWT was applied, using either foam or gauze, at -50,-75, -100, -125, -150, or -175 mm Hg. Microvascular blood flow was measured in muscle tissue, subcutaneous tissue, and in the wound bed, at 0.5, 1, and 2.5 cm from the wound edge, using laser Doppler velocimetry. Similar patterns of blood flow response were observed when using foam or gauze. At 2.5 cm from the wound edge there was an increase in microvascular blood flow, while blood flow was decreased closer (0.5 cm) to the wound edge. The blood flow effects were similar at the different levels of negative pressure in muscle tissue, subcutaneous tissue, and in the wound bed. Altered microvascular blood flow to the wound edge may be one of the mechanisms by which NPWT facilitates healing.

引用

页码：676 / 681

页数：6

共 23 条

[1] Vacuum-assisted closure: A new method for wound control and treatment: Clinical experience [J].

Argenta, LC ;

Morykwas, MJ .

ANNALS OF PLASTIC SURGERY, 1997, 38 (06) :563-576

[2] Vacuum-assisted closure: State of clinic art [J].

Argenta, Louis C. ;

Morykwas, Michael J. ;

Marks, Malcolm W. ;

DeFranzo, Anthony J. ;

Molnar, Joseph A. ;

David, Lisa R. .

PLASTIC AND RECONSTRUCTIVE SURGERY, 2006, 117 (07) :127S-142S

[3]

Banwell Paul, 2006, J Tissue Viability, V16, P16

[4] Surgical wound case studies with the versatile 1 wound vacuum system for negative pressure wound therapy [J].

Campbell, PE ;

Bonham, PA .

JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING, 2006, 33 (02) :176-190

[5] Retrospective clinical evaluation of gauze-based negative pressure wound therapy [J].

Campbell, Penny E. ;

Smith, Gary S. ;

Smith, Jennifer M. .

INTERNATIONAL WOUND JOURNAL, 2008, 5 (02) :280-286

[6]

CHARIKER M E, 1989, Contemporary Surgery, V34, P59

[7]

Chen Shao-Zong, 2005, Asian J Surg, V28, P211, DOI 10.1016/S1015-9584(09)60346-8

[8] Microdeformational wound therapy - Effects on angiogenesis and matrix metalloproteinases in chronic wounds of 3 debilitated patients [J].

Greene, AK ;

Puder, M ;

Roy, R ;

Arsenault, D ;

Kwei, S ;

Moses, MA ;

Orgill, DP .

ANNALS OF PLASTIC SURGERY, 2006, 56 (04) :418-422

[9]

GRIMM A, 2008, STRAHLENTHER ONKOL, V3, P144

[10] A technique to visualize wound bed microcirculation and the acute effect of negative pressure [J].

Ichioka, Shigeru ;

Watanabe, Hiromi ;

Sekiya, Naomi ;

Shibata, Masahiro ;

Nakatsuka, Takashi .

WOUND REPAIR AND REGENERATION, 2008, 16 (03) :460-465

← 1 2 3 →