HPLC-based bioseparations using molecularly imprinted polymers

被引：33

作者：

Haginaka, J ^{[1
]}

机构：

[1] Mukogawa Womens Univ, Fac Pharmaceut Sci, Nishinomiya, Hyogo 6638179, Japan

来源：

BIOSEPARATION | 2001年 / 10卷 / 06期

关键词：

molecular imprinting; molecularly imprinted polymer; affinity separation; bioseparation; chiral separation; chiral stationary phases;

D O I：

10.1023/A:1021550005389

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

HPLC-based separations of amino acids and peptides, nucleotide bases, drugs, sugars and steroids using molecularly imprinted polymers (MIPs) have been reviewed in this article. The molecular recognition mechanisms of the template molecules on the MIPs in organic and aqueous eluents were discussed. Furthermore, new polymerization methods suitable for preparations of HPLC columns and packing materials using molecular imprinting techniques, and their applications to HPLC-based separations are also dealt with.

引用

页码：337 / 351

页数：15

共 97 条

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Allender CJ, 1997, CHIRALITY, V9, P238, DOI 10.1002/(SICI)1520-636X(1997)9:3<238::AID-CHIR6>3.3.CO

[2]

2-F

[3] MOLECULAR RECOGNITION IN SYNTHETIC-POLYMERS - PREPARATION OF CHIRAL STATIONARY PHASES BY MOLECULAR IMPRINTING OF AMINO-ACID AMIDES [J].