Natural killer cells and pregnancy

被引：930

作者：

Moffett-King, A ^{[1
]}

机构：

[1] Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, England

来源：

NATURE REVIEWS IMMUNOLOGY | 2002年 / 2卷 / 09期

基金：

美国国家卫生研究院; 英国惠康基金;

关键词：

D O I：

10.1038/nri886

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The fetus is considered to be an allograft that, paradoxically, survives pregnancy despite the laws of classical transplantation immunology. There is no direct contact of the mother with the embryo, only with the extraembryonic placenta as it implants in the uterus. No convincing evidence of uterine maternal T-cell recognition of placental trophoblast cells has been found, but instead, there might be maternal allorecognition mediated by uterine natural killer cells that recognize unusual fetal trophoblast MHC ligands.

引用

页码：656 / 663

页数：8

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