Biosynthesis of polybrominated aromatic organic compounds by marine bacteria

被引：239

作者：

Agarwal, Vinayak ^{[1
]}

El Gamal, Abrahim A. ^{[1
]}

Yamanaka, Kazuya ^{[2
]}

Poth, Dennis ^{[2
]}

Kersten, Roland D. ^{[2
]}

Schorn, Michelle ^{[2
]}

Allen, Eric E. ^{[1
,2
,3
]}

Moore, Bradley S. ^{[1
,2
,4
]}

机构：

[1] Univ Calif San Diego, Scripps Inst Oceanog, Ctr Oceans & Human Hlth, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Biomed, La Jolla, CA 92093 USA

[3] Univ Calif San Diego, Div Biol Sci, La Jolla, CA 92093 USA

[4] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USA

来源：

NATURE CHEMICAL BIOLOGY | 2014年 / 10卷 / 08期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

CANDIDA-PARAPSILOSIS CBS604; DIPHENYL ETHERS; ANTIBIOTIC PENTABROMOPSEUDILIN; DEPENDENT MONOOXYGENASE; MASS-SPECTROMETRY; NATURAL-PRODUCTS; IN-VITRO; SP-NOV; IDENTIFICATION; 4-HYDROXYBENZOATE;

D O I：

10.1038/nchembio.1564

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Polybrominated diphenyl ethers (PBDEs) and polybrominated bipyrroles are natural products that bioaccumulate in the marine food chain. PBDEs have attracted widespread attention because of their persistence in the environment and potential toxicity to humans. However, the natural origins of PBDE biosynthesis are not known. Here we report marine bacteria as producers of PBDEs and establish a genetic and molecular foundation for their production that unifies paradigms for the elaboration of bromophenols and bromopyrroles abundant in marine biota. We provide biochemical evidence of marine brominases revealing decarboxylative-halogenation enzymology previously unknown among halogenating enzymes. Biosynthetic motifs discovered in our study were used to mine sequence databases to discover unrealized marine bacterial producers of organobromine compounds.

引用

页码：640 / U182

页数：11

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