hSKCa3:: No association of the polymorphic CAG repeat with bipolar affective disorder and schizophrenia

被引:12
作者
Rohrmeier, T
Putzhammer, A
Schoeler, A
Sartor, H
Dallinger, P
Nöthen, MM
Propping, P
Knapp, M
Albus, M
Borrmann, M
Knothe, K
Kreiner, R
Franzek, E
Lichtermann, O
Rietschel, M
Maier, W
Klein, HE
Eichhammer, P
机构
[1] Univ Regensburg, Dept Psychiat, D-93042 Regensburg, Germany
[2] Univ Bonn, Dept Human Genet, D-53111 Bonn, Germany
[3] Univ Bonn, Dept Med Stat, D-53105 Bonn, Germany
[4] Mental State Hosp, D-85529 Haar, Germany
[5] Univ Dresden, Dept Psychiat, D-01307 Dresden, Germany
[6] Univ Wurzburg, Dept Psychiat, D-97080 Wurzburg, Germany
[7] Univ Bonn, Dept Psychiat, D-53105 Bonn, Germany
关键词
hSKCa3; bipolar disorder; schizophrenia; transmission disequilibrium test; association; trinucleotide repeat;
D O I
10.1097/00041444-199912000-00001
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
hSKCa3 is a neuronal small conductance calcium-activated potassium channel, which contains a polyglutamine tract, encoded by a polymorphic CAG repeat in the gene. Since an association between longer alleles of this CAG repeat and bipolar disorder or schizophrenia has been reported, we genotyped the polymorphic CAG repeat in 91 German family trios of patients with bipolar disorder I and used the transmission disequilibrium test (TDT) to test for association. Applying a dichotomized model (less than or equal to 19 or >19 CAG triplets), we found no evidence for an association of longer alleles with bipolar disorder (TDT = 0.75, P = 0.386). Regarding the whole range of alleles, there was no preference in transmitting the larger of the two observed alleles from parents to the affected offspring. In parallel we performed an independent case-control study on German patients with bipolar disorder and schizophrenia. Again,ve did not detect an overrepresentation of longer CAG repeats in patients. Thus, our data do not support the hypothesis that longer CAG repeats in the hSkCa3 gene contribute to the susceptibility for bipolar disorder and schizophrenia. (C) 1999 Lippincott Williams & Wilkins.
引用
收藏
页码:169 / 175
页数:7
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