The influence of wear particles in the expression of osteoclastogenesis factors by osteoblasts

被引：70

作者：

Pioletti, DP ^{[1
]}

Kottelat, A

机构：

[1] Ecole Polytech Fed Lausanne, Swiss Fed Inst Technol, Ctr Orthoped Res, Bone Bioengn Grp, CH-1015 Lausanne, Switzerland

[2] Hop Orthoped Suisse Romande, Lausanne, Switzerland

来源：

BIOMATERIALS | 2004年 / 25卷 / 27期

关键词：

orthopedic wear particles; osteolysis; osteoblast; RANKL; OPG; CSF-1;

D O I：

10.1016/j.biomaterials.2004.01.053

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Orthopedic implant failures are often associated with peri-implant osteolysis. Particles generated from the wear process have been suspected to play an important role in this situation. Indeed, the peri-implant osteolysis could be due to the presence of particles stimulating the osteoclastogenesis process. We hypothesize then that the presence of a low particle concentration positively influences osteoblasts to produce osteoclastogenesis factors. If true, this hypothesis would then support the idea that the particles could be at the origin of the process leading to implant loosening. To check the validity of this hypothesis, we quantified in vitro the production of different genes involved in the osteoclastogenesis process using primary isolated human osteoblasts treated or not with particles. Results showed that low concentrations of particles might have a stimulating effect on osteoblasts to produce osteoclastogenesis factors as demonstrated by the increase of RANKL and CSF-1 gene expression in the particle group. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：5803 / 5808

页数：6

共 49 条

[1] The effects of particulate cobalt, chromium and cobalt-chromium alloy on human osteoblast-like cells in vitro [J].

Allen, MJ ;

Myer, BJ ;

Millett, PJ ;

Rushton, N .

JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, 1997, 79B (03) :475-482

[2] Periprosthetic bone resorption - Particles versus movement [J].

Aspenberg, P ;

Herbertsson, P .

JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, 1996, 78B (04) :641-646

[3]

BECHTOLD JE, 1995, P 41 ORS, P767

[4] PRODUCTION OF OSTEOCALCIN BY HUMAN-BONE CELLS-INVITRO - EFFECTS OF 1,25(OH)2D3, 24,25(OH)2D3, PARATHYROID-HORMONE, AND GLUCOCORTICOIDS [J].

BERESFORD, JN ;

GALLAGHER, JA ;

POSER, JW ;

RUSSELL, RGG .

METABOLIC BONE DISEASE & RELATED RESEARCH, 1984, 5 (05) :229-234

[5] Osteoclast differentiation and activation [J].

Boyle, WJ ;

Simonet, WS ;

Lacey, DL .

NATURE, 2003, 423 (6937) :337-342

[6] In vivo RANK signaling blockade using the receptor activator of NF-κB:Fc effectively prevents and ameliorates wear debris-induced osteolysis via osteoclast depletion without inhibiting osteogenesis [J].

Childs, LM ;

Paschalis, EP ;

Xing, LP ;

Dougall, WC ;

Anderson, D ;

Boskey, AL ;

Puzas, JE ;

Rosier, RN ;

O'Keefe, RJ ;

Boyce, BF ;

Schwarz, EM .

JOURNAL OF BONE AND MINERAL RESEARCH, 2002, 17 (02) :192-199

[7]

CLARKE IC, 1992, AM SOC TEST MATER, V1144, P7, DOI 10.1520/STP14848S

[8] RANKL is an essential cytokine mediator of polymethylmethacrylate particle-induced osteoclastogenesis [J].

Clohisy, JC ;

Frazier, E ;

Hirayama, T ;

Abu-Amer, Y .

JOURNAL OF ORTHOPAEDIC RESEARCH, 2003, 21 (02) :202-212

[9] Factors regulating osteoclast formation in human tissues adjacent to peri-implant bone loss:: expression of receptor activator NFκB, RANK ligand and osteoprotegerin [J].

Crotti, TN ;

Smith, MD ;

Findlay, DM ;

Zreiqat, H ;

Ahern, MJ ;

Weedon, H ;

Hatzinikolous, G ;

Capone, M ;

Holding, C ;

Haynes, DR .

BIOMATERIALS, 2004, 25 (04) :565-573

[10] Effect of polymer molecular weight and addition of calcium stearate on response of MG63 osteoblast-like cells to UHMWPE particles [J].

Dean, DD ;

Lohmann, CH ;

Sylvia, VL ;

Köster, G ;

Liu, Y ;

Schwartz, Z ;

Boyan, BD .

JOURNAL OF ORTHOPAEDIC RESEARCH, 2001, 19 (02) :179-186

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