Crystal structure of epoxomicin:20S proteasome reveals a molecular basis for selectivity of α′,β′-epoxyketone proteasome inhibitors

被引：271

作者：

Groll, M ^{[1
]}

Kim, KB

Kairies, N

Huber, R

Crews, CM

机构：

[1] Max Planck Inst Biochem, D-82152 Martinsried, Germany

[2] Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA

[3] Yale Univ, Dept Pharmacol, New Haven, CT 06520 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2000年 / 122卷 / 06期

关键词：

D O I：

10.1021/ja993588m

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

页码：1237 / 1238

页数：2

共 21 条

[1] RULES FOR RING-CLOSURE
BALDWIN, JE
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1976, (18) : 734 - 736
[2] A PROTEIN CATALYTIC FRAMEWORK WITH AN N-TERMINAL NUCLEOPHILE IS CAPABLE OF SELF-ACTIVATION
BRANNIGAN, JA
DODSON, G
DUGGLEBY, HJ
MOODY, PCE
SMITH, JL
TOMCHICK, DR
MURZIN, AG
[J]. NATURE, 1995, 378 (6555) : 416 - 419
[3] PENICILLIN ACYLASE HAS A SINGLE-AMINO-ACID CATALYTIC CENTER
DUGGLEBY, HJ
TOLLEY, SP
HILL, CP
DODSON, EJ
DODSON, G
MOODY, PCE
[J]. NATURE, 1995, 373 (6511) : 264 - 268
[4] Towards subunit-specific proteasome inhibitors:: synthesis and evaluation of peptide α′,β′-epoxyketones
Elofsson, M
Splittgerber, U
Myung, J
Mohan, R
Crews, CM
[J]. CHEMISTRY & BIOLOGY, 1999, 6 (11): : 811 - 822
[5] Featherstone C, 1997, MOL MED TODAY, V3, P367
[6] The catalytic sites of 20S proteasomes and their role in subunit maturation:: A mutational and crystallographic study
Groll, M
Heinemeyer, W
Jäger, S
Ullrich, T
Bochtler, M
Wolf, DH
Huber, R
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (20) : 10976 - 10983
[7] Structure of 20S proteasome from yeast at 2.4 angstrom resolution
Groll, M
Ditzel, L
Lowe, J
Stock, D
Bochtler, M
Bartunik, HD
Huber, R
[J]. NATURE, 1997, 386 (6624) : 463 - 471
[8] STUDIES ON THE YEAST PROTEASOME UNCOVER ITS BASIC STRUCTURAL FEATURES AND MULTIPLE IN-VIVO FUNCTIONS
HILT, W
HEINEMEYER, W
WOLF, DH
[J]. ENZYME & PROTEIN, 1993, 47 (4-6) : 189 - 201
[9] TMC-52A to D, novel cysteine proteinase inhibitors, produced by Gliocladium sp.
Isshiki, K
Nishio, M
Sakurai, N
Uchida, T
Okuda, T
Komatsubara, S
[J]. JOURNAL OF ANTIBIOTICS, 1998, 51 (07) : 629 - 634
[10] Proteasome inhibition by the natural products epoxomicin and dihydroeponemycin: Insights into specificity and potency
Kim, KB
Myung, J
Sin, N
Crews, CM
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1999, 9 (23) : 3335 - 3340

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