Magnetic resonance spectroscopy detects brain injury and predicts cognitive functioning in children with brain injuries

被引：44

作者：

Yeo, Ronald A. ^{[1
]}

Phillips, John P.

Jung, Rex E.

Brown, April J.

Campbell, Richard C.

Brooks, William M.

机构：

[1] Univ New Mexico, Dept Psychol, Albuquerque, NM 87131 USA

[2] Univ New Mexico, Sch Med, Dept Neurol, Albuquerque, NM 87131 USA

[3] MIND Inst, Albuquerque, NM USA

[4] Univ New Mexico, Sch Med, Dept Psychiat, Albuquerque, NM USA

[5] Univ Kansas, Med Ctr, Sch Med, Hogland Brain Imaging Ctr, Kansas City, KS USA

来源：

JOURNAL OF NEUROTRAUMA | 2006年 / 23卷 / 10期

关键词：

cognitive; outcome; pediatric; spectroscopy; traumatic brain injury;

D O I：

10.1089/neu.2006.23.1427

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Proton magnetic resonance spectroscopy (H-1-MRS) and neuropsychological assessment were utilized in a longitudinal investigation of traumatic brain injury (TBI) in children. A spectroscopic imaging protocol was implemented, and neurometabolite ratios of NAA/Cre and Cho/Cre were calculated for anterior and posterior halves of a supraventricular slab of brain tissue. NAA/Cre was reduced and Cho/Cre increased in TBI patients as compared to controls, for both brain regions. Each ratio predicted aspects of neuropsychological performance; though the specific relationships varied somewhat by region and function. Anterior NAA/Cre increased and anterior Cho/Cre decreased from 3 to 21 weeks post-injury, suggesting neurometabolic recovery.

引用

页码：1427 / 1435

页数：9

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