Antimicrobial Susceptibility and Mutations Involved in Clarithromycin Resistance in Helicobacter pylori Isolates from Patients in the Western Central Region of Colombia

被引：34

作者：

Alvarez, Adalucy ^{[1
]}

Ignacio Moncayo, Jose ^{[1
]}

Javier Santacruz, Jorge ^{[1
]}

Santacoloma, Mario ^{[2
]}

Fernanda Corredor, Luisa ^{[1
]}

Reinosa, Elizabeth ^{[1
]}

机构：

[1] Univ Tecnol Pereira, Ctr Biol Mol & Biotecnol, Lab Microbiol & Parasitol, Pereira, Colombia

[2] Univ Caldas, Dept Clin Quirurg, Manizales, Colombia

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 09期

关键词：

RIBOSOMAL-RNA GENE; FRAGMENT LENGTH POLYMORPHISM; ANTIBIOTIC-RESISTANCE; MACROLIDE RESISTANCE; AGAR DILUTION; STRAINS; PREVALENCE; METRONIDAZOLE; CHILDREN; TETRACYCLINE;

D O I：

10.1128/AAC.00145-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Resistance to metronidazole, clarithromycin, and amoxicillin (amoxicilline) was found in 82, 3.8, and 1.9% of 106 Helicobacter pylori isolates, respectively. No tetracycline-resistant isolates were found. In all of the clarithromycin-resistant isolates, only one point mutation was present, either A2143G or A2142G. Our results indicate that metronidazole should not be included in the empirical treatment of H. pylori infection in this region.

引用

页码：4022 / 4024

页数：3

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