Copper-catalyzed double N-alkenylation of amides:: An efficient synthesis of di- or trisubstituted N-acylpyrroles

被引：111

作者：

Yuan, Xiyuan

Xu, Xiaobing

Zhou, Xiaobo

Yuan, Jiwei

Mai, Lugen

Li, Yanzhong

机构：

[1] E China Normal Univ, Dept Chem, Shanghai 200062, Peoples R China

[2] E China Normal Univ, Shanghai Key Lab Green Chem & Chem Proc, Shanghai 200062, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2007年 / 72卷 / 04期

关键词：

D O I：

10.1021/jo062194s

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient copper-catalyzed double alkenylation of amides with (1Z,3Z)-1,4-diiodo-1,3-dienes is reported for the first time. The reactions proceed to afford di- or trisubstituted N-acylpyrroles in good to excellent yields using CuI as the catalyst, Cs2CO3 as the base, and rac-trans-N,N'-dimethylcyclohexane-1,2-diamine as the ligand.

引用

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页码：1510 / 1513

页数：4

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