Synthesis and biological activity of pyrrole, pyrroline and pyrrolidine derivatives with two aryl groups on adjacent positions

被引：591

作者：

Bellina, Fabio ^{[1
]}

Rossi, Renzo ^{[1
]}

机构：

[1] Univ Pisa, Dipartimento Chim & Chim Ind, I-56126 Pisa, Italy

来源：

TETRAHEDRON | 2006年 / 62卷 / 31期

关键词：

pyrroles; pyrrolines; pyrrolidines; synthesis; bioactivity; natural products;

D O I：

10.1016/j.tet.2006.05.024

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis and biological activity of pyrrole, pyrroline and pyrrolidine derivatives with two aryl groups on adjacent positions was investigated. Pyrrole derivatives with two aryl groups on adjacent positions include important classes of marine natural products, some of which display remarkable biological and pharmacological properties. These classes of heterocyclic derivatives have stimulated great interest from synthetic and medicinal chemists. Interest have been shown in terms of synthetic and atom efficiency, in the development and application of selective methods to form C-C bonds through C-H activation of hetero arenes, in which only one component of the transition metal-catalyzed reaction needed to posses a reactive functional group. It was found that the vicinal diaryl-substituted pyrrole, pyrroline and pyrrolidine derivatives include natural and unnatural compounds with notable biological and pharmacological properties.

引用

页码：7213 / 7256

页数：44

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