Preparation of novel aza-1,7-annulated indoles and their conversion to potent indolocarbazole kinase inhibitors

被引：17

作者：

Al-awar, RS ^{[1
]}

Ray, JE

Hecker, KA

Joseph, S

Huang, JP

Shih, C

Brooks, HB

Spencer, CD

Watkins, SC

Schultz, RM

Considine, EL

Faul, MM

Sullivan, KA

Kolis, SP

Carr, MA

Zhang, FM

机构：

[1] Eli Lilly & Co, Lilly Res Labs, Discovery Chem Res, Indianapolis, IN 46285 USA

[2] Eli Lilly & Co, Lilly Res Labs, Canc Res Div, Indianapolis, IN 46285 USA

[3] Eli Lilly & Co, Chem Proc Res & Dev, Indianapolis, IN 46285 USA

[4] Eli Lilly & Co, Sci & Technol, Indianapolis, IN 46285 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 15期

关键词：

cdk4; indolocarbazoles;

D O I：

10.1016/j.bmcl.2004.05.088

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of novel aza-1,7-annulated indoles was achieved and these were converted to indolocarbazoles that proved to be potent kinase inhibitors. These compounds were also evaluated in a human colon carcinoma cell line and proved to be good antiproliferative agents. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：3925 / 3928

页数：4

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