Natriuretic peptides in heart failure: should therapy be guided by BNP levels?

被引：62

作者：

O'Donoghue, Michelle ^{[1
,2
]}

Braunwald, Eugene ^{[1
,2
]}

机构：

[1] Harvard Univ, TIMI Study Grp, Div Cardiovasc, Brigham & Womens Hosp,Med Sch, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA

来源：

NATURE REVIEWS CARDIOLOGY | 2010年 / 7卷 / 01期

关键词：

LEFT-VENTRICULAR DYSFUNCTION; MEDICINE PRACTICE GUIDELINES; TRIAL VAL-HEFT; CARDIAC RESYNCHRONIZATION; CLINICAL UTILIZATION; NATIONAL-ACADEMY; BRAIN; IMPACT; CARVEDILOL; MORTALITY;

D O I：

10.1038/nrcardio.2009.197

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Heart failure (HF) is a leading cause of morbidity and mortality worldwide. Testing for natriuretic peptide markers, such as B-type natriuretic peptide (BNP) or N-terminal proBNP (NT-proBNP), has emerged as an important tool for the diagnosis and risk stratification of patients with HF. However, questions remain regarding the potential role for natriuretic peptides to guide therapy in patients with HF. In this Review, we address the underlying assumptions and the existing evidence supporting a natriuretic-peptide-guided approach to the outpatient management of HF.

引用

页码：13 / 20

页数：8

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