Multiple sclerosis in childhood: Clinical features of 149 cases

被引:250
作者
Ghezzi, A
Deplano, V
Faroni, J
Grasso, MG
Liguori, M
Marrosu, G
Pozzilli, C
Simone, IL
Zaffaroni, M
机构
[1] UNIV CAGLIARI,DIPARTIMENTO NEUROSCI,CAGLIARI,ITALY
[2] UNIV ROMA LA SAPIENZA,DIPARTIMENTO SCI NEUROL,I-00185 ROME,ITALY
[3] OSPED RIABILITAZ ROMA,IRCCS S LUCIA,ROME,ITALY
[4] UNIV BARI,CLIN MALATTIE NERVOSE & MENTALI,BARI,ITALY
来源
MULTIPLE SCLEROSIS | 1997年 / 3卷 / 01期
关键词
multiple sclerosis; child neurology; age of onset; frequency;
D O I
10.1177/135245859700300105
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
From the retrospective study of 3375 patients effected by clinically definite or probable multiple sclerosis (MS), 149 patients were collected with onset of the disease before the age of 16 years (4.4%). Female/male ratio was higher than that of the adult onset MS (AOMS) population (2.2 vs 1.6) particularly at ages of onset after 12 years (3.0, P=0.007 vs AOMS). Among initial symptoms, those suggesting brainstem dysfunction (25%) were more frequent compared to other systems and compared to AOMs symptoms, motor and sensory disturbances were slightly less frequent (respectively 17.5% and 18.3%). Optic neuritis appeared in 16.5% of cases with onset in childhood and in 16.2% of cases with AOMS, cerebellar disturbances respectively in 9.1% and 7.7%. The first interattack interval and the clinical course of early onset MS did not differ significantly from AOMS. In early onset MS patients with disease duration <8 years, cases with EDSS>6 were slightly more frequent than in the AOMS group (P=0.04). The frequency of cases for different levels of disability was similar for disease duration >8 years.
引用
收藏
页码:43 / 46
页数:4
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