Association of Marijuana Smoking with Oropharyngeal and Oral Tongue Cancers: Pooled Analysis from the INHANCE Consortium

被引：50

作者：

Marks, Morgan A. ^{[1
]}

Chaturvedi, Anil K. ^{[1
]}

Kelsey, Karl ^{[4
]}

Straif, Kurt ^{[5
]}

Berthiller, Julien ^{[5
,6
,7
]}

Schwartz, Stephen M. ^{[9
]}

Smith, Elaine ^{[10
]}

Wyss, Annah ^{[11
]}

Brennan, Paul ^{[5
]}

Olshan, Andrew F. ^{[11
]}

Wei, Qingyi ^{[12
]}

Sturgis, Erich M. ^{[12
]}

Zhang, Zuo-Feng ^{[13
]}

Morgenstern, Hal ^{[14
,15
]}

Muscat, Joshua ^{[16
]}

Lazarus, Philip ^{[16
]}

McClean, Michael ^{[17
]}

Chen, Chu ^{[9
]}

Vaughan, Thomas L. ^{[9
]}

Wunsch-Filho, Victor ^{[18
]}

Curado, Maria Paula ^{[8
]}

Koifman, Sergio ^{[19
]}

Matos, Elena ^{[22
]}

Menezes, Ana ^{[20
]}

Daudt, Alexander W. ^{[21
]}

Fernandez, Leticia ^{[23
]}

Posner, Marshall ^{[2
]}

Boffetta, Paolo ^{[8
,24
]}

Lee, Yuan-Chin Amy ^{[25
]}

Hashibe, Mia ^{[25
]}

D'Souza, Gypsyamber ^{[3
]}

机构：

[1] NCI, Div Canc Epidemiol & Genet, Rockville, MD USA

[2] Johns Hopkins Sch Med, Baltimore, MD USA

[3] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA

[4] Brown Univ, Sch Med, Dept Community Hlth, Providence, RI 02912 USA

[5] Int Agcy Res Canc, F-69372 Lyon, France

[6] Hosp Civils Lyon, Lyon, France

[7] Univ Lyon 1, Equipe Accueil 4129, F-69365 Lyon, France

[8] Int Prevent Res Inst, Lyon, France

[9] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA

[10] Univ Iowa, Coll Publ Hlth, Iowa City, IA USA

[11] Univ N Carolina, Sch Publ Hlth, Chapel Hill, NC USA

[12] Univ Texas MD Anderson Canc Ctr, Dept Head & Neck Surg & Epidemiol, Houston, TX 77030 USA

[13] Univ Calif Los Angeles, Sch Publ Hlth, Los Angeles, CA 90024 USA

[14] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA

[15] Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA

[16] Penn State Coll Med, Hershey, PA USA

[17] Boston Univ, Sch Publ Hlth, Boston, MA USA

[18] Univ Sao Paulo, Fac Saude Publ, Sao Paulo, Brazil

[19] Fundacao Oswaldo Cruz, Escola Nacl Saude Publ, Rio De Janeiro, Brazil

[20] Univ Fed Pelotas, Pelotas, Brazil

[21] Hosp Clin Porto Alegre, Port Alegre, Brazil

[22] Univ Buenos Aires, Inst Oncol Angel H Roffo, Buenos Aires, DF, Argentina

[23] Inst Oncol & Radiobiol, Havana, Cuba

[24] Mt Sinai Sch Med, Tisch Canc Inst, New York, NY USA

[25] Univ Utah, Sch Med, Salt Lake City, UT USA

来源：

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | 2014年 / 23卷 / 01期

基金：

巴西圣保罗研究基金会;

关键词：

SQUAMOUS-CELL CARCINOMA; AGED; 45; YEARS; HUMAN-PAPILLOMAVIRUS; RISK-FACTORS; ENDOCANNABINOID SYSTEM; SENSITIVITY-ANALYSIS; INCIDENCE TRENDS; UNITED-STATES; CANNABIS USE; HEAD;

D O I：

10.1158/1055-9965.EPI-13-0181

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: The incidence of oropharyngeal and oral tongue cancers has increased over the last 20 years which parallels increased use of marijuana among individuals born after 1950. Methods: A pooled analysis was conducted comprising individual-level data from nine case-control studies from the United States and Latin America in the INHANCE consortium. Self-reported information on marijuana smoking, demographic, and behavioral factors was obtained from 1,921 oropharyngeal cases, 356 oral tongue cases, and 7,639 controls. Results: Compared with never marijuana smokers, ever marijuana smokers had an elevated risk of oropharyngeal [adjusted OR (aOR), 1.24; 95% confidence interval (CI): 1.06-1.47] and a reduced risk of oral tongue cancer (aOR, 0.47; 95% CI, 0.29, 0.75). The risk of oropharyngeal cancer remained elevated among never tobacco and alcohol users. The risk of oral tongue cancer was reduced among never users of tobacco and alcohol. Sensitivity analysis adjusting for potential confounding by HPV exposure attenuated the association of marijuana use with oropharyngeal cancer (aOR, 0.99; 95% CI, 0.71-1.25), but had no effect on the oral tongue cancer association. Conclusions: These results suggest that the association of marijuana use with head and neck carcinoma may differ by tumor site. Impact: The associations of marijuana use with oropharyngeal and oral tongue cancer are consistent with both possible pro-and anticarcinogenic effects of cannabinoids. Additional work is needed to rule out various sources of bias, including residual confounding by HPV infection and misclassification of marijuana exposure. (C) 2013 AACR.

引用

页码：160 / 171

页数：12

共 47 条

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