Circulating Long Noncoding RNA, LIPCAR, Predicts Survival in Patients With Heart Failure

被引：771

作者：

Kumarswamy, Regalla ^{[1
]}

Bauters, Christophe ^{[3
,4
,5
,6
]}

Volkmann, Ingo ^{[1
]}

Maury, Fleur ^{[3
,4
]}

Fetisch, Jasmin ^{[1
]}

Holzmann, Angelika ^{[1
]}

Lemesle, Gilles ^{[3
,4
,5
,6
]}

de Groote, Pascal ^{[3
,4
,5
]}

Pinet, Florence ^{[3
,4
,5
]}

Thum, Thomas ^{[1
,2
,7
]}

机构：

[1] Hannover Med Sch, IFB Tx, IMTTS, D-30625 Hannover, Germany

[2] Hannover Med Sch, REBIRTH Excellence Cluster, D-30625 Hannover, Germany

[3] Univ Lille Nord France, INSERM, U744, Lille, France

[4] Inst Pasteur, Lille, France

[5] Ctr Hosp Reg & Univ Lille, F-59037 Lille, France

[6] Fac Med Lille, F-59045 Lille, France

[7] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London, England

来源：

CIRCULATION RESEARCH | 2014年 / 114卷 / 10期

关键词：

cardiac biomarkers; cardiac remodeling; circulating lncRNA; heart failure; mitochondria; myocardial infarction; RNA; long noncoding; ACUTE MYOCARDIAL-INFARCTION; NATRIURETIC PEPTIDE; RISK STRATIFICATION; PLASMA; MARKER;

D O I：

10.1161/CIRCRESAHA.114.303915

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Rationale: Long noncoding RNAs represent a novel class of molecules regulating gene expression. Long noncoding RNAs are present in body fluids, but their potential as biomarkers was never investigated in cardiovascular disease. Objective: To study the role of long noncoding RNAs as potential biomarkers in heart disease. Methods and Results: Global transcriptomic analyses were done in plasma RNA from patients with or without left ventricular remodeling after myocardial infarction. Regulated candidates were validated in 3 independent patient cohorts developing cardiac remodeling and heart failure (788 patients). The mitochondrial long noncoding RNA uc022bqs.1 (LIPCAR) was downregulated early after myocardial infarction but upregulated during later stages. LIPCAR levels identified patients developing cardiac remodeling and were independently to other risk markers associated with future cardiovascular deaths. Conclusions: LIPCAR is a novel biomarker of cardiac remodeling and predicts future death in patients with heart failure.

引用

页码：1569 / 1575

页数：7

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