TBAF-Mediated Aldol Reaction of β-Allenoates: Regio- and Stereoselective Synthesis of (2E,4E)-4-Carbinol Alkadienoates

被引：19

作者：

Aponte, Jose C. ^{[1
]}

Hammond, Gerald B. ^{[1
]}

Xu, Bo ^{[1
]}

机构：

[1] Univ Louisville, Dept Chem, Louisville, KY 40292 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 74卷 / 12期

基金：

美国国家科学基金会;

关键词：

VINYLOGOUS MANNICH REACTION; CHIRAL AMBIDENT NUCLEOPHILES; EFFICIENT SYNTHESIS; CATALYZED SYNTHESIS; ALKYNYL ESTERS; ALLENYL ESTERS; ACID; FRAGMENT; 2-HYDROXY-3,4-DIENOATES; REARRANGEMENT;

D O I：

10.1021/jo900567m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The aldol reaction of beta-allenoate with use of a commercial THF solution of tetrabutylammonium fluoride (TBAF) yielded polyfunctionalized (2E,4E)-4-carbinol alkadienoate-a valuable building block-in highly regio- and stereoselective fashion.

引用

页码：4623 / 4625

页数：3

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