The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing

被引：1395

作者：

Gaffen, Sarah L. ^{[1
]}

Jain, Renu ^{[2
]}

Garg, Abhishek V. ^{[1
]}

Cua, Daniel J. ^{[2
]}

机构：

[1] Div Rheumatol & Clin Immunol, Pittsburgh, PA 15261 USA

[2] Merck Res Labs, Palo Alto, CA 94304 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2014年 / 14卷 / 09期

基金：

美国国家卫生研究院;

关键词：

GROWTH-FACTOR-BETA; NF-KAPPA-B; CHRONIC MUCOCUTANEOUS CANDIDIASIS; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; T(H)17 CELL-DIFFERENTIATION; GENOME-WIDE ASSOCIATION; IL-17-PRODUCING T-CELLS; INNATE LYMPHOID-CELLS; NECROSIS-FACTOR-ALPHA; FACTOR BATF CONTROLS;

D O I：

10.1038/nri3707

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Following the discovery of T helper 17 (T(H)17) cells, the past decade has witnessed a major revision of the T-H subset paradigm and substantial progress has been made in deciphering the molecular mechanisms of T cell lineage commitment and function. In this Review, we focus on the recent advances that have been made regarding the transcriptional control of T(H)17 cell plasticity and stability, as well as the effector functions of TH17 cells, and we highlight the mechanisms of IL-17 signalling in mesenchymal and barrier epithelial tissues. We also discuss the emerging clinical data showing that IL-17-specific and IL-23-specific antibody treatments are remarkably effective for treating many immune-mediated inflammatory diseases.

引用

页码：585 / 600

页数：16

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