Reference values for relative numbers of natural killer cells in cattle blood

被引：39

作者：

Kulberg, S ^{[1
]}

Boysen, P ^{[1
]}

Storset, AK ^{[1
]}

机构：

[1] Norwegian Sch Vet Sci, Dept Food Safety & Infect Biol, N-0033 Oslo, Norway

来源：

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY | 2004年 / 28卷 / 09期

关键词：

natural killer cells; NKp46; cattle; age-dependency; reference value; lymphocyte subsets; innate immunity; disease resistance;

D O I：

10.1016/j.dci.2004.02.004

中图分类号：

S9 [水产、渔业];

学科分类号：

0908 ;

摘要：

Natural killer (NK) cells have been studied in humans and rodents for almost 30 years, but little is known about NK cells in other mammals, such as cattle. Recently, a monoclonal antibody directed against bovine NKp46, a receptor that is expressed exclusively on NK cells, was developed. We have utilized this antibody to study the relative numbers of NK cells in blood of 254 cattle at different ages. The highest relative number of NK cells was observed in young calves, and gradually decreased with age to a bottom level in heifers, followed by a moderate increase in adults. Relative numbers of NK cells in cattle were generally lower than in humans, but age-related changes in bovine NK cells showed similar tendencies as reported in humans. The present material provides a source for reference values for NK cells in cattle at various ages. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：941 / 948

页数：8

共 38 条

[1]

Altman DG, 1990, PRACTICAL STAT MED R

[2] Age-dependent changes in peripheral blood lymphocyte subpopulations in cattle: A longitudinal study [J].

Ayoub, IA ;

Yang, TJ .

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 1996, 20 (05) :353-363

[3] Rapid changes occur in the percentage of circulating bovine WC1+ γδ Th1 cells [J].

Baldwin, CL ;

Sathiyaseelan, T ;

Rocchi, M ;

McKeever, D .

RESEARCH IN VETERINARY SCIENCE, 2000, 69 (02) :175-180

[4] Immunophenotyping of blood lymphocytes in childhood - Reference values for lymphocyte subpopulations [J].

ComansBitter, WM ;

deGroot, R ;

vandenBeemd, R ;

Neijens, HJ ;

Hop, WCJ ;

Groeneveld, K ;

Hooijkaas, H ;

vanDongen, JJM .

JOURNAL OF PEDIATRICS, 1997, 130 (03) :388-393

[5] Natural killer cell activity and delivery: Possible influence of cortisol and anesthetic agents - A study on newborn cord blood [J].

De Amici, D ;

Gasparoni, A ;

Chirico, G ;

Ceriana, P ;

Bartoli, A ;

Ramajoli, I ;

Moretta, A .

BIOLOGY OF THE NEONATE, 1999, 76 (06) :348-354

[6] AGE-RELATED-CHANGES IN HUMAN BLOOD LYMPHOCYTE SUBPOPULATIONS [J].

ERKELLERYUKSEL, FM ;

DENEYS, V ;

YUKSEL, B ;

HANNET, I ;

HULSTAERT, F ;

HAMILTON, C ;

MACKINNON, H ;

STOKES, LT ;

MUNHYESHULI, V ;

VANLANGENDONCK, F ;

DEBRUYERE, M ;

BACH, BA ;

LYDYARD, PM .

JOURNAL OF PEDIATRICS, 1992, 120 (02) :216-222

[7]

EVANS CW, 1994, IMMUNOLOGY, V82, P229

[8] Elements of immunity - The instructive role of innate immunity in the acquired immune response [J].

Fearon, DT ;

Locksley, RM .

SCIENCE, 1996, 272 (5258) :50-54

[9] NK cell compartments and their activation by dendritic cells [J].

Ferlazzo, G ;

Münz, C .

JOURNAL OF IMMUNOLOGY, 2004, 172 (03) :1333-1339

[10] Immunity and protection against Brucella abortus [J].

Golding, B ;

Scott, DE ;

Scharf, O ;

Huang, LY ;

Zaitseva, M ;

Lapham, C ;

Eller, N ;

Golding, H .

MICROBES AND INFECTION, 2001, 3 (01) :43-48

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