Invasive zygomycosis in hematopoietic stem cell transplant recipients receiving voriconazole prophylaxis

被引：227

作者：

Siwek, GT

Dodgson, KJ

de Magalhaes-Silverman, M

Bartelt, LA

Kilborn, SB

Hoth, PL

Diekema, DJ

Pfaller, MA

机构：

[1] Univ Iowa, Carver Coll Med, Dept Internal Med, Div Infect Dis, Iowa City, IA 52242 USA

[2] Univ Iowa, Carver Coll Med, Dept Internal Med, Div Hematol Oncol, Iowa City, IA 52242 USA

[3] Univ Iowa, Carver Coll Med, Dept Pathol, Div Med Microbiol, Iowa City, IA USA

[4] Univ Iowa, Coll Publ Hlth, Dept Epidemiol, Iowa City, IA USA

来源：

CLINICAL INFECTIOUS DISEASES | 2004年 / 39卷 / 04期

关键词：

D O I：

10.1086/422723

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We report 4 cases of invasive zygomycosis in hematopoietic stem cell transplant recipients, all occurring after May 2003, when voriconazole began to be used as antifungal prophylaxis. No cases of zygomycosis had been detected in this population in the 3 years prior to May 2003. All 4 patients were receiving immunosuppressive therapy for presumed graft-versus-host disease. Profoundly immunosuppressed patients receiving voriconazole prophylaxis remain at risk for less-common pathogens that are intrinsically resistant to this agent.

引用

页码：584 / 587

页数：4

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