Characterization of the human immune response to the UK anthrax vaccine

被引：40

作者：

Baillie, L ^{[1
]}

Townend, T

Walker, N

Eriksson, U

Williamson, D

机构：

[1] USN, Med Res Ctr, Biol Def Res Directorate, Silver Spring, MD 20910 USA

[2] Dstl Porton Down, Salisbury SP4 0JQ, Wilts, England

[3] NDRE, Inst Microbiol, SE-90182 Umea, Sweden

来源：

FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY | 2004年 / 42卷 / 02期

关键词：

anthrax vaccine; lethal toxin; immune responses; epitopes;

D O I：

10.1016/j.femsim.2004.05.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The anthrax bipartite lethal toxin (protective antigen (PA) and lethal factor (LF))-specific antibody responses of humans receiving the UK licensed anthrax vaccine were determined. The PA-specific IgG response peaked two weeks post immunization and fell back to pre-boost levels by week 12. The heterogeneity of the host population modulated the extent of the PA-specific antibody response. Significantly lower levels of LF-specific antibodies were also detected. Vaccinated individuals recognized the same PA epitope as the protective mouse lethal toxin neutralizing monoclonal 2133 suggesting that this may also be a target for human protection. (C) 2004 Published by Elsevier B.V. on behalf of the Federation of European Microbiological Societies.

引用

页码：267 / 270

页数：4

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