Control of cell polarity by noncanonical Wnt signaling in C-elegans

被引:29
作者
Herman, MA [1 ]
机构
[1] Kansas State Univ, Div Biol, Program Mol Cellular & Dev Biol, Manhattan, KS 66506 USA
关键词
C; elegans; Wnt signaling; cell polarity; spindle orientation; asymmetric cell division;
D O I
10.1016/S1084-9521(02)00051-4
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The three Caenorhabditis elegans beta-catenin each function in distinct processes: BAR-1 in canonical Wnt signaling that controls cell fates and cell migrations, HMP-2 in cell adhesion and WRM-1 in Wnt signaling pathways that function in conjunction with a mitogen-activated kinase (MAPK) pathway to control the orientations, or cell Polarities, of cells that undergo asymmetric cell divisions. In addition, WRM-1 does not interact with the canonical beta-catenin binding site in POP-1/Tcf. Thus, Wnt signaling through WRM-1 is noncanonical and, except for one division that might not include any of the three C. elegans beta-calenin, controls cell polarity in C. elegans.
引用
收藏
页码:233 / 241
页数:9
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