Control of cell polarity by noncanonical Wnt signaling in C-elegans

被引：29

作者：

Herman, MA ^{[1
]}

机构：

[1] Kansas State Univ, Div Biol, Program Mol Cellular & Dev Biol, Manhattan, KS 66506 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2002年 / 13卷 / 03期

关键词：

C; elegans; Wnt signaling; cell polarity; spindle orientation; asymmetric cell division;

D O I：

10.1016/S1084-9521(02)00051-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The three Caenorhabditis elegans beta-catenin each function in distinct processes: BAR-1 in canonical Wnt signaling that controls cell fates and cell migrations, HMP-2 in cell adhesion and WRM-1 in Wnt signaling pathways that function in conjunction with a mitogen-activated kinase (MAPK) pathway to control the orientations, or cell Polarities, of cells that undergo asymmetric cell divisions. In addition, WRM-1 does not interact with the canonical beta-catenin binding site in POP-1/Tcf. Thus, Wnt signaling through WRM-1 is noncanonical and, except for one division that might not include any of the three C. elegans beta-calenin, controls cell polarity in C. elegans.

引用

页码：233 / 241

页数：9

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