Links between replication, recombination and genome instability in eukaryotes

被引：99

作者：

Flores-Rozas, H ^{[1
]}

Kolodner, RD

机构：

[1] Univ Calif San Diego, Sch Med, Ludwig Inst Canc Res, Ctr Canc, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Sch Med, Dept Med, La Jolla, CA 92093 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2000年 / 25卷 / 04期

关键词：

D O I：

10.1016/S0968-0004(00)01568-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Double-strand breaks in DNA can be repaired by homologous recombination including break-induced replication. In this reaction, the end of a broken DNA invades an intact chromosome and primes DNA replication resulting in the synthesis of an intact chromosome. Break-induced replication has also been suggested to cause different types of genome rearrangements.

引用

页码：196 / 200

页数：5

共 48 条

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