Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation

被引：179

作者：

Lutterbach, B ^{[1
]}

Hiebert, SW ^{[1
]}

机构：

[1] Vanderbilt Univ, Dept Biochem, Nashville, TN 37232 USA

来源：

GENE | 2000年 / 245卷 / 02期

关键词：

deacetylation; myeloid; runt; transcriptional repression;

D O I：

10.1016/S0378-1119(00)00014-7

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Chromosomal translocations affecting the AML-1 gene are among the most frequent aberrations found in acute leukemia. Because the AML-1 transcription factor is a critical regulator of hematopoeitic cell development, normal homeostasis is disrupted in cells containing these translocations. In this review we describe the mechanisms of transcriptional activation and repression by AML-1 and how this transcriptional control is disrupted by the chromosomal translocations that affect AML-1. Finally, we discuss how the mechanism of transcriptional repression by these chromosomal translocation fusion proteins is a possible target of therapeutic intervention in acute leukemia. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：223 / 235

页数：13

共 133 条

[1] The leukemic protein core binding factor β (CBFβ)-smooth-muscle myosin heavy chain sequesters CBFα2 into cytoskeletal filaments and aggregates
Adya, N
Stacy, T
Speck, NA
Liu, PP
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (12) : 7432 - 7443
[2] Negative regulation of granulocytic differentiation in the myeloid precursor cell line 32Dcl3 by ear-2, a mammalian homolog of Drosophila seven-up, and a chimeric leukemogenic gene, AML1/ETO(MTG8)
Ahn, MY
Huang, G
Bae, SC
Wee, HJ
Kim, WY
Ito, Y
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (04) : 1812 - 1817
[3] Groucho-dependent and -independent repression activities of runt domain proteins
Aronson, BD
Fisher, AL
Blechman, K
Caudy, M
Gergen, JP
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1997, 17 (09) : 5581 - 5587
[4] BANERJEE U, 1997, LOOP TR RESTRUCT COM, V3, P1
[5] Banker DE, 1998, CLIN CANCER RES, V4, P3051
[6] ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCR alpha enhancer function
Bruhn, L
Munnerlyn, A
Grosschedl, R
[J]. GENES & DEVELOPMENT, 1997, 11 (05) : 640 - 653
[7] FUNCTIONAL-ANALYSIS OF THE INDIVIDUAL ENHANCER CORE SEQUENCES OF POLYOMAVIRUS - CELL-SPECIFIC UNCOUPLING OF DNA-REPLICATION FROM TRANSCRIPTION
CAMPBELL, BA
VILLARREAL, LP
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1988, 8 (05) : 1993 - 2004
[8] The fusion gene Cbfb-MYH11 blocks myeloid differentiation and predisposes mice to acute myelomonocytic leukaemia
Castilla, LH
Garrett, L
Adya, N
Orlic, D
Dutra, A
Anderson, S
Owens, J
Eckhaus, M
Bodine, D
Liu, PP
[J]. NATURE GENETICS, 1999, 23 (02) : 144 - 146
[9] Failure of embryonic hematopoiesis and lethal hemorrhages in mouse embryos heterozygous for a knocked-in leukemia gene CBFB-MYH11
Castilla, LH
Wijmenga, C
Wang, Q
Stacy, T
Speck, NA
Eckhaus, M
MarinPadilla, M
Collins, FS
WynshawBoris, A
Liu, PP
[J]. CELL, 1996, 87 (04) : 687 - 696
[10] Modulation of TEL transcription activity by interaction with the ubiquitin-conjugating enzyme UBC9
Chakrabarti, SR
Sood, R
Ganguly, S
Bohlander, S
Shen, ZY
Nucifora, G
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (13) : 7467 - 7472

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