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Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation

被引：179
作者：
Lutterbach, B [1 ]
Hiebert, SW [1 ]
机构：
[1] Vanderbilt Univ, Dept Biochem, Nashville, TN 37232 USA
来源：
GENE | 2000年 / 245卷 / 02期
关键词：
deacetylation; myeloid; runt; transcriptional repression;
D O I：
10.1016/S0378-1119(00)00014-7
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Chromosomal translocations affecting the AML-1 gene are among the most frequent aberrations found in acute leukemia. Because the AML-1 transcription factor is a critical regulator of hematopoeitic cell development, normal homeostasis is disrupted in cells containing these translocations. In this review we describe the mechanisms of transcriptional activation and repression by AML-1 and how this transcriptional control is disrupted by the chromosomal translocations that affect AML-1. Finally, we discuss how the mechanism of transcriptional repression by these chromosomal translocation fusion proteins is a possible target of therapeutic intervention in acute leukemia. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：223 / 235
页数：13
相关论文
共 133 条
  • [61] A large variety of alternatively spliced and differentially expressed mRNAs are encoded by the human acute myeloid leukemia gene AML1
    Levanon, D
    Bernstein, Y
    Negreanu, V
    Ghozi, MC
    BarAm, I
    Aloya, R
    Goldenberg, D
    Lotem, J
    Groner, Y
    [J]. DNA AND CELL BIOLOGY, 1996, 15 (03) : 175 - 185
  • [62] Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors
    Levanon, D
    Goldstein, RE
    Bernstein, Y
    Tang, H
    Goldenberg, D
    Stifani, S
    Paroush, Z
    Groner, Y
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (20) : 11590 - 11595
  • [63] AML1, AML2, AND AML3, THE HUMAN MEMBERS OF THE RUNT DOMAIN GENE-FAMILY - CDNA STRUCTURE, EXPRESSION, AND CHROMOSOMAL LOCALIZATION
    LEVANON, D
    NEGREANU, V
    BERNSTEIN, Y
    BARAM, I
    AVIVI, L
    GRONER, Y
    [J]. GENOMICS, 1994, 23 (02) : 425 - 432
  • [64] THE ACIDIC TRANSCRIPTIONAL ACTIVATION DOMAINS OF VP16 AND P53 BIND THE CELLULAR REPLICATION PROTEIN-A AND STIMULATE INVITRO BPV-1 DNA-REPLICATION
    LI, R
    BOTCHAN, MR
    [J]. CELL, 1993, 73 (06) : 1207 - 1221
  • [65] FUSION BETWEEN TRANSCRIPTION FACTOR CBF-BETA/PEBP2-BETA AND A MYOSIN HEAVY-CHAIN IN ACUTE MYELOID-LEUKEMIA
    LIU, P
    TARLE, SA
    HAJRA, A
    CLAXTON, DF
    MARLTON, P
    FREEDMAN, M
    SICILIANO, MJ
    COLLINS, FS
    [J]. SCIENCE, 1993, 261 (5124) : 1041 - 1044
  • [66] The inv(16) encodes an acute myeloid leukemia 1 transcriptional corepressor
    Lutterbach, B
    Hou, Y
    Durst, KL
    Hiebert, SW
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (22) : 12822 - 12827
  • [67] A mechanism of repression by acute myeloid leukemia-1, the target of multiple chromosomal translocations in acute leukemia
    Lutterbach, B
    Westendorf, JJ
    Linggi, B
    Isaac, S
    Seto, E
    Hiebert, SW
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (01) : 651 - 656
  • [68] ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors
    Lutterbach, B
    Westendorf, JJ
    Linggi, B
    Patten, A
    Moniwa, M
    Davie, JR
    Huynh, KD
    Bardwell, VJ
    Lavinsky, RM
    Rosenfeld, MG
    Glass, C
    Seto, E
    Hiebert, SW
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (12) : 7176 - 7184
  • [69] The MYND motif is required for repression of basal transcription from the multidrug resistance 1 promoter by the t(8;21) fusion protein
    Lutterbach, B
    Sun, DX
    Schuetz, J
    Hiebert, SW
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (06) : 3604 - 3611
  • [70] MANOUKIAN AS, 1993, DEVELOPMENT, V118, P785
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