Weibel-Palade bodies-sentinels of acute stress

被引：27

作者：

Goligorsky, Michael S. ^{[1
,2
]}

Patschan, Daniel ^{[3
]}

Kuo, Mei-Chuan ^{[4
]}

机构：

[1] Renal Res Inst, Dept Med, Valhalla, NY 10595 USA

[2] Renal Res Inst, Dept Pharmacol, Valhalla, NY 10595 USA

[3] Univ Gottingen, Sch Med, Dept Internal Med, D-3400 Gottingen, Germany

[4] Kaohsiung Med Univ Hosp, Div Nephrol, Dept Internal Med, Kaohsiung, Taiwan

来源：

NATURE REVIEWS NEPHROLOGY | 2009年 / 5卷 / 07期

关键词：

ENDOTHELIAL PROGENITOR CELLS; BODY EXOCYTOSIS; ISCHEMIA/REPERFUSION INJURY; MYOCARDIAL-INFARCTION; ANGIOPOIETIN-2; INTERLEUKIN-8; DISEASE; NEOVASCULARIZATION; COMPARTMENTS; STIMULATION;

D O I：

10.1038/nrneph.2009.87

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

100201 [内科学]; 100221 [泌尿外科学];

摘要：

Weibel-Palade bodies are uniquely present in endothelial cells and harbor a range of bioactive substances that participate in hemostasis, vasomotion, inflammation and fibrinolysis, in addition to modulating vascular permeability, angiogenic sprouting, and stem cell mobilization. this perspectives article examines the latest insights into the biogenesis of these organelles and the cellular and molecular mechanisms of their exocytosis. in addition, we advance two hypotheses on the pathogenic role of these organelles: first, in the development of endothelial dysfunction associated with the reduction of nitric oxide bioavailability and accumulation of peroxynitrite and second, as a first-line response to acute stress that determines the balance between regenerative and proinflammatory signals.

引用

页码：423 / 426

页数：4

共 32 条

[1]

Expression of IL-8 during reperfusion of renal allografts is dependent on ischemic time [J].

Araki, M ;

Fahmy, N ;

Zhou, LM ;

Kumon, H ;

Krishnamurthi, V ;

Goldfarb, D ;

Modlin, C ;

Flechner, S ;

Novick, AC ;

Fairchild, RL .

TRANSPLANTATION, 2006, 81 (05) :783-788

[2]

VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells [J].

Asahara, T ;

Takahashi, T ;

Masuda, H ;

Kalka, C ;

Chen, DH ;

Iwaguro, H ;

Inai, Y ;

Silver, M ;

Isner, JM .

EMBO JOURNAL, 1999, 18 (14) :3964-3972

[3]

ITF1697, a stable Lys-Pro-containing peptide, inhibits Weibel-Palade body exocytosis induced by ischemia/reperfusion and pressure elevation [J].

Bertuglia, Silvia ;

Ichimura, Hideo ;

Fossati, Gianluca ;

Parthasarathi, Kaushik ;

Leoni, Flavio ;

Modena, Daniela ;

Cremonesi, Piero ;

Bhattacharya, Jahar ;

Mascagni, Paolo .

MOLECULAR MEDICINE, 2007, 13 (11-12) :615-624

[4]

High-mobility group box 1 activates integrin-dependent homing of endothelial progenitor cells [J].

Chavakis, Emmanouil ;

Hain, Andreas ;

Vinci, Maria ;

Carmona, Guillaume ;

Bianchi, Marco E. ;

Vajkoczy, Peter ;

Zeiher, Andreas M. ;

Chavakis, Triantafyllos ;

Dimmeler, Stefanie .

CIRCULATION RESEARCH, 2007, 100 (02) :204-212

[5]

Activation of Ca2+-dependent signaling by TLR2 [J].

Chun, Jarin ;

Prince, Alice .

JOURNAL OF IMMUNOLOGY, 2006, 177 (02) :1330-1337

[6]

Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells [J].

Daly, Christopher ;

Pasnikowski, Elizabeth ;

Burova, Elena ;

Wong, Vivian ;

Aldrich, Thomas H. ;

Griffiths, Jennifer ;

Ioffe, Ella ;

Daly, Thomas J. ;

Fandl, James P. ;

Papadopoulos, Nick ;

McDonald, Donald M. ;

Thurston, Gavin ;

Yancopoulos, George D. ;

Rudge, John S. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (42) :15491-15496

[7]

Toll-like receptors 2-deficient mice are protected against postischemic coronary endothelial dysfunction [J].

Favre, Julie ;

Musette, Philippe ;

Douin-Echinard, Victorine ;

Laude, Karine ;

Henry, Jean-Paul ;

Arnal, Jean-Francois ;

Thuillez, Christian ;

Richard, Vincent .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2007, 27 (05) :1064-1071

[8]

The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Paladebodies [J].

Fiedler, U ;

Scharpfenecker, M ;

Koidl, S ;

Hegen, A ;

Grunow, V ;

Schmidt, JM ;

Kriz, W ;

Thurston, G ;

Augustin, HG .

BLOOD, 2004, 103 (11) :4150-4156

[9]

Endothelial nitric oxide synthase in vascular disease -: From marvel to menace [J].

Förstermann, U ;

Münzel, T .

CIRCULATION, 2006, 113 (13) :1708-1714

[10]

Paracrine mitogenic effect of human endothelial progenitor cells: role of interleukin-8 [J].

He, TR ;

Peterson, TE ;

Katusic, ZS .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2005, 289 (02) :H968-H972

← 1 2 3 4 →