Enzyme evolution - Design by necessity

被引：16

作者：

Petsko, GA ^{[1
]}

机构：

[1] Brandeis Univ, Rosenstiel Basic Med Sci Res Ctr, Waltham, MA 02454 USA

来源：

NATURE | 2000年 / 403卷 / 6770期

关键词：

D O I：

10.1038/35001176

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Creating new enzymes by ‘rational design’ has proved to be extremely difficult. A new approach combines structural modification with natural selection — so-called ‘directed evolution’. With this technique, one enzyme in a biosynthetic pathway can be converted into another enzyme with a completely different function.

引用

页码：606 / 607

页数：2

共 14 条

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