ON THE ORIGIN OF ENZYMATIC SPECIES

被引：110

作者：

PETSKO, GA

KENYON, GL

GERLT, JA

RINGE, D

KOZARICH, JW

机构：

[1] UNIV CALIF SAN FRANCISCO, DEPT PHARMACEUT CHEM, SAN FRANCISCO, CA 94143 USA

[2] UNIV MARYLAND, DEPT CHEM & BIOCHEM, COLL PK, MD 20742 USA

[3] MERCK SHARP & DOHME LTD, RAHWAY, NJ 07065 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1993年 / 18卷 / 10期

关键词：

D O I：

10.1016/0968-0004(93)90091-Z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The diversity of enzyme catalytic function is remarkable, particularly when one considers that ancestral life forms must have started with a much smaller ensemble of proteins. In this article, we discuss the evolution of the mandelate pathway in pseudomonads as an example of how catalytic diversity may have evolved. We suggest that existing enzymes that catalyse the chemistry needed to accomplish a transformation were recruited, followed by the evolution of specific binding.

引用

收藏

页码：372 / 376

页数：5

相关论文

共 23 条

[1] ON THE 3-DIMENSIONAL STRUCTURE AND CATALYTIC MECHANISM OF TRIOSE PHOSPHATE ISOMERASE [J].

ALBER, T ;

BANNER, DW ;

BLOOMER, AC ;

PETSKO, GA ;

PHILLIPS, D ;

RIVERS, PS ;

WILSON, IA .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 1981, 293 (1063) :159-171

[2] CLONING AND COMPLETE NUCLEOTIDE-SEQUENCE DETERMINATION OF THE CATB GENE ENCODING CIS,CIS-MUCONATE LACTONIZING ENZYME [J].

ALDRICH, TL ;

FRANTZ, B ;

GILL, JF ;

KILBANE, JJ ;

CHAKRABARTY, AM .

GENE, 1987, 52 (2-3) :185-195

[3] THE ORIGIN OF MUTANTS [J].

CAIRNS, J ;

OVERBAUGH, J ;

MILLER, S .

NATURE, 1988, 335 (6186) :142-145

[4] THE EVOLUTION OF ALPHA-BETA-BARREL ENZYMES [J].

FARBER, GK ;

PETSKO, GA .

TRENDS IN BIOCHEMICAL SCIENCES, 1990, 15 (06) :228-&

[5] MANDELATE RACEMASE FROM PSEUDOMONAS-PUTIDA - SUBUNIT COMPOSITION AND ABSOLUTE DIVALENT METAL-ION REQUIREMENT [J].

FEE, JA ;

HEGEMAN, GD ;

KENYON, GL .

BIOCHEMISTRY, 1974, 13 (12) :2528-2532

[6]

Gerlt JA., 1992, CURR OPIN STRUC BIOL, V2, P736, DOI [10.1016/0959-440X(92)90209-P, DOI 10.1016/0959-440X(92)90209-P]

[7] CRYSTAL-STRUCTURE OF MUCONATE LACTONIZING ENZYME AT 3 A RESOLUTION [J].

GOLDMAN, A ;

OLLIS, DL ;

STEITZ, TA .

JOURNAL OF MOLECULAR BIOLOGY, 1987, 194 (01) :143-153

[8] THE ENZYMATIC CONVERSION OF MANDELIC ACID TO BENZOIC ACID .3. FRACTIONATION AND PROPERTIES OF THE SOLUBLE ENZYMES [J].

GUNSALUS, CF ;

STANIER, RY ;

GUNSALUS, IC .

JOURNAL OF BACTERIOLOGY, 1953, 66 (05) :548-553

[9] THE ENZYMATIC CONVERSION OF MANDELIC ACID TO BENZOIC ACID .1. GROSS FRACTIONATION OF THE SYSTEM INTO SOLUBLE AND PARTICULATE COMPONENTS [J].

GUNSALUS, IC ;

GUNSALUS, CF ;

STANIER, RY .

JOURNAL OF BACTERIOLOGY, 1953, 66 (05) :538-542

[10] MECHANISM OF THE REACTION CATALYZED BY MANDELATE RACEMASE .3. ASYMMETRY IN REACTIONS CATALYZED BY THE H297N MUTANT [J].

LANDRO, JA ;

KALLARAKAL, AT ;

RANSOM, SC ;

GERLT, JA ;

KOZARICH, JW ;

NEIDHART, DJ ;

KENYON, GL .

BIOCHEMISTRY, 1991, 30 (38) :9274-9281