Th9 cells, new players in adaptive immunity

被引：211

作者：

Schmitt, Edgar ^{[1
]}

Klein, Matthias ^{[1
]}

Bopp, Tobias ^{[1
]}

机构：

[1] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Immunol, D-55131 Mainz, Germany

来源：

TRENDS IN IMMUNOLOGY | 2014年 / 35卷 / 02期

关键词：

T helper cell; interleukin-9; Th9; cytokine; lymphocyte differentiation; transcription factor; plasticity; CD4(+) T-CELLS; INTERFERON-REGULATORY FACTOR-4; ALLERGIC AIRWAY INFLAMMATION; TGF-BETA; IL-9; PRODUCTION; IN-VIVO; LUNG INFLAMMATION; GATA3; EXPRESSION; IFN-GAMMA; KAPPA-B;

D O I：

10.1016/j.it.2013.10.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Upon antigen-specific stimulation, naive CD4(+)T cells have the potential to differentiate into various T helper (Th) cell subsets. Earlier models of Th cell differentiation focused on IFN-gamma-producing Thl cells and IL-4-secreting Th2 cells. The discovery of additional CD4(+) Th cell subsets has extended our understanding of Th cell differentiation beyond this dichotomy. Among these is the recently described Th9 cell subset, which preferentially produces interleUkin (IL)-9. Here, we review the latest developments in Th9 cell development and differentiation, focusing on contributing environmental signals, and discuss potential physiological and pathophysiological functions of these cells. We describe the challenges inherent to unambiguously defining roles for Th9 cells using the available experimental animal models, and suggest new experimental models to address these concerns.

引用

页码：61 / 68

页数：8

共 79 条

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