Changes in Lung Function in Young Cystic Fibrosis Patients Between Two Courses of Intravenous Antibiotics Against Pseudomonas aeruginosa

被引：4

作者：

Beghin, Laurent ^{[1
,2
,3
,4
]}

Michaud, Laurent ^{[1
,2
,5
]}

Loeuille, Guy-Andre ^{[6
]}

Wizla-Derambure, Nathalie ^{[1
,2
,5
]}

Sayah, Hocine ^{[3
,4
]}

Sardet, Anne ^{[7
]}

Thumerelle, Caroline ^{[5
]}

Deschildre, Antoine ^{[5
]}

Turck, Dominique ^{[1
,2
,5
]}

Gottrand, Frederic ^{[1
,2
,5
]}

机构：

[1] Univ Lille 2, EA 3925, Lille, France

[2] Cyst Fibrosis Ctr, Div Gastroenterol Hepatol & Nutr, Lille, France

[3] Inserm Clin Invest Ctr Lille, CIC 9301, CH&U, Lille, France

[4] Univ Hosp, Lille, France

[5] Jeanne de Flandre Univ Childrens Hosp, Dept Pediat, Fac Med, Lille, France

[6] Gen Hosp Dunkerque, Cyst fibrosis Ctr, Dunkerque, France

[7] Gen Hosp Lens, Cyst fibrosis Ctr, Lens, France

来源：

PEDIATRIC PULMONOLOGY | 2009年 / 44卷 / 05期

关键词：

cystic fibrosis; nutritional status; Pseudomonas aeruginosa; body composition; lung function; antibiotic therapy; BODY-COMPOSITION; LONG-TERM; PULMONARY-FUNCTION; CHILDREN; ADOLESCENTS; THERAPY; IMPEDANCE; FAT;

D O I：

10.1002/ppul.21017

中图分类号：

R72 [儿科学];

学科分类号：

100202 [儿科学];

摘要：

Background and Aims: Repeated intravenous antibiotic therapy (IVAT) against chronic pulmonary infection with Pseudomonas aeruginosa is often necessary in cystic fibrosis patients (CF). The aim of this study was to monitor kinetics of degradation of pulmonary and nutritional status after IVAT in CF patients. Methods: Lung function, nutritional status and physical activity (PA) were measured for 21 CF patients (mean +/- SD age, 16 +/- 1.9 years; 9 boys) who were chronically colonized by P. aeruginosa Each parameter was measured every 15 days during 3-6 months. Results: Nutritional status as well as PA did not change in the interval of 2 IVAT. In contrary, lung function worsened with a decrease of -14.6% of the FEV1 (P < 0.05). Conclusion: In CF, there is a progressive decrease in lung function without any evident deterioration of nutritional status and PA between two IVAT. Pediatr Pulmonol. 2009; 44:464-471. (C) 2009 Wiley-Liss, Inc.

引用

页码：464 / 471

页数：8

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