Hedgehog-Gli Signaling Pathway Inhibitors as Anticancer Agents

被引：135

作者：

Mahindroo, Neeraj ^{[1
]}

Punchihewa, Chandanamali ^{[1
]}

Fujii, Naoaki ^{[1
]}

机构：

[1] St Jude Childrens Res Hosp, Dept Chem Biol & Therapeut, Memphis, TN 38105 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2009年 / 52卷 / 13期

关键词：

SMALL-MOLECULE INHIBITOR; BASAL-CELL CARCINOMAS; SONIC-HEDGEHOG; HUMAN HOMOLOG; POTENT INHIBITORS; CANDIDATE GENE; RETINOIC ACID; MOUSE MODEL; CANCER; MEDULLOBLASTOMA;

D O I：

10.1021/jm801420y

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：3829 / 3845

页数：17

共 150 条

[91]

Park HL, 2000, DEVELOPMENT, V127, P1593

[92] Identification of a palmitic acid-modified form of human Sonic hedgehog [J].

Pepinsky, RB ;

Zeng, CH ;

Wen, DY ;

Rayhorn, P ;

Baker, DP ;

Williams, KP ;

Bixler, SA ;

Ambrose, CM ;

Garber, EA ;

Miatkowski, K ;

Taylor, FR ;

Wang, EA ;

Galdes, A .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (22) :14037-14045

[93] Identification and structure-activity relationships of ortho-biphenyl carboxamides as potent Smoothened antagonists inhibiting the Hedgehog signaling pathway [J].

Peukert, Stefan ;

Jain, Rishi K. ;

Geisser, Adrian ;

Sun, Yingchuan ;

Zhang, Rui ;

Bourret, Aaron ;

Carlson, Adam ;

DaSilva, Jennifer ;

Ramamurthy, Arun ;

Kelleher, Joseph F. .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (02) :328-331

[94]

PINK M, 2008, ANN M AM ASS CANC RE

[95] Prediction of central nervous system embryonal tumour outcome based on gene expression [J].

Pomeroy, SL ;

Tamayo, P ;

Gaasenbeek, M ;

Sturla, LM ;

Angelo, M ;

McLaughlin, ME ;

Kim, JYH ;

Goumnerova, LC ;

Black, PM ;

Lau, C ;

Allen, JC ;

Zagzag, D ;

Olson, JM ;

Curran, T ;

Wetmore, C ;

Biegel, JA ;

Poggio, T ;

Mukherjee, S ;

Rifkin, R ;

Califano, A ;

Stolovitzky, G ;

Louis, DN ;

Mesirov, JP ;

Lander, ES ;

Golub, TR .

NATURE, 2002, 415 (6870) :436-442

[96] Cholesterol modification of hedgehog signaling proteins in animal development [J].

Porter, JA ;

Young, KE ;

Beachy, PA .

SCIENCE, 1996, 274 (5285) :255-259

[97] Hedgehog signalling in colorectal tumour cells: Induction of apoptosis with cyclopamine treatment [J].

Qualtrough, D ;

Buda, A ;

Gaffield, W ;

Williams, AC ;

Paraskeva, C .

INTERNATIONAL JOURNAL OF CANCER, 2004, 110 (06) :831-837

[98] Medulloblastoma: Molecular genetics and animal models [J].

Raffel, C .

NEOPLASIA, 2004, 6 (04) :310-322

[99] Structural analogues of smoothened intracellular loops as potent inhibitors of hedgehog pathway and cancer cell growth [J].

Remsberg, Jarrett R. ;

Lou, Hong ;

Tarasov, Sergey G. ;

Dean, Michael ;

Tarasova, Nadya I. .

JOURNAL OF MEDICINAL CHEMISTRY, 2007, 50 (18) :4534-4538

[100] Retinaldehyde dehydrogenase 2 (RALDH2)-mediated retinoic acid synthesis regulates early mouse embryonic forebrain development by controlling FGF and sonic hedgehog signaling [J].

Ribes, V ;

Wang, ZX ;

Dollé, P ;

Niederreither, K .

DEVELOPMENT, 2006, 133 (02) :351-361

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