A mouse model of Borrelia meningitis after intradermal injection

被引：28

作者：

GarciaMonco, JC

Miller, NS

Backenson, PB

Anda, P

Benach, JL

机构：

[1] SUNY STONY BROOK,DEPT PATHOL,STONY BROOK,NY 11794

[2] INST SALUD CARLOS III,CTR NACL MICROBIOL VIROL & IMMUNOL SANITARIAS,MADRID,SPAIN

[3] HOSP GALDACANO,SECC NEUROL,VIZCAYA,SPAIN

[4] JOHNS HOPKINS UNIV,SCH MED,DEPT PATHOL,BALTIMORE,MD 21205

来源：

JOURNAL OF INFECTIOUS DISEASES | 1997年 / 175卷 / 05期

关键词：

D O I：

10.1086/593681

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Both young and adult C3H/HeN mice developed meningitis within 3 weeks of intradermal inoculation with a newly identified uncultivable Borrelia species, an agent of human relapsing fever, Meningoencephalitis with perivascular infiltrates and plexitis developed at similar to 25 days after inoculation, Infiltrates were composed of B and plasma cells and monocytes, This model recreated the meningitis associated with spirochetal infections through an intradermal route of infection.

引用

页码：1243 / 1245

页数：3