SIRT1, Is It a Tumor Promoter or Tumor Suppressor?

被引：271

作者：

Deng, Chu-Xia ^{[1
]}

机构：

[1] NIDDKD, Genet Dev & Dis Branch, NIH, Bethesda, MD 20892 USA

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES | 2009年 / 5卷 / 02期

基金：

美国国家卫生研究院;

关键词：

SIRT1; tumor promoter; tumor suppressor; DNA damage repair; SMALL-MOLECULE ACTIVATORS; DNA-DAMAGE RESPONSE; CALORIC RESTRICTION; CELL-SURVIVAL; DEACETYLASE SIRT1; PROSTATE-CANCER; REGULATES SIRT1; BREAST-CANCER; LIFE-SPAN; MICE;

D O I：

10.7150/ijbs.5.147

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

SIRT1 has been considered as a tumor promoter because of its increased expression in some types of cancers and its role in inactivating proteins that are involved in tumor suppression and DNA damage repair. However, recent studies demonstrated that SIRT1 levels are reduced in some other types of cancers, and that SIRT1 deficiency results in genetic instability and tumorigenesis, while overexpression of SIRT1 attenuates cancer formation in mice heterozygous for tumor suppressor p53 or APC. Here, I review these recent findings and discuss the possibility that activation of SIRT1 both extends lifespan and inhibits cancer formation.

引用

页码：147 / 152

页数：6

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