Clinical Assessment of a Novel Recombinant Simian Adenovirus ChAdOx1 as a Vectored Vaccine Expressing Conserved Influenza A Antigens

被引：174

作者：

Antrobus, Richard D. ^{[1
]}

Coughlan, Lynda ^{[1
]}

Berthoud, Tamara K. ^{[1
]}

Dicks, Matthew D. ^{[1
]}

Hill, Adrian V. S. ^{[1
]}

Lambe, Teresa ^{[1
]}

Gilbert, Sarah C. ^{[1
]}

机构：

[1] Univ Oxford, Jenner Inst, Oxford, England

来源：

MOLECULAR THERAPY | 2014年 / 22卷 / 03期

关键词：

T-CELL IMMUNOGENICITY; SEASONAL INFLUENZA; HIV-1; VACCINE; HUMANS; IMMUNITY; RESPONSES; EFFICACY; PROTECTION; MVA-NP+M1; POTENT;

D O I：

10.1038/mt.2013.284

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Adenoviruses are potent vectors for inducing and boosting cellular immunity to encoded recombinant antigens. However, the widespread seroprevalence of neutralizing antibodies to common human adenovirus serotypes limits their use. Simian adenoviruses do not suffer from the same drawbacks. We have constructed a replication-deficient chimpanzee adenovirus-vectored vaccine expressing the conserved influenza antigens, nucleoprotein (NP), and matrix protein 1 (M1). Here, we report safety and T-cell immunogenicity following vaccination with this novel recombinant simian adenovirus, ChAdOx1 NP+M1, in a first in human dose-escalation study using a 3+3 study design, followed by boosting with modified vaccinia virus Ankara expressing the same antigens in some volunteers. We demonstrate ChAdOx1 NP+M1 to be safe and immunogenic. ChAdOx1 is a promising vaccine vector that could be used to deliver vaccine antigens where strong cellular immune responses are required for protection.

引用

页码：668 / 674

页数：7

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