Cytotoxic lymphocytes and cardiac electrophysiology

被引：29

作者：

Binah, O ^{[1
]}

机构：

[1] Technion Israel Inst Technol, Bernard Katz Minerva Ctr Cell Biophys, Bruce Rappaport Fac Med, Rappaport Family Inst Res Med Sci, IL-31096 Haifa, Israel

来源：

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY | 2002年 / 34卷 / 09期

关键词：

cytotoxic lymphocytes; ventricular myocytes; perforin/granzymes; Fas receptor; 1,4,5-inositol triphosphate;

D O I：

10.1006/jmcc.2002.2056

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

It is widely recognized that immune effector mechanisms contribute to cardiac dysfunction in major cardiac pathologies. such as myocarditis and the consequent dilated cardiomyopathy, Chagas' disease and heart transplant rejection. Of the wealth of immune mechanisms known to affect cardiac function. this review will deal with the adverse effects caused by cytotoxic T lymphocytes (CTL. CD4(+) and CD8(+) T lymphocytes). which participate in a broad range of heart pathologies. The interaction between cytotoxic lymphocytes and their target cells can set off two different effector mechanisms: (1) The perforin/granzymes, and (2) The Fas/FasL. In this review, I will discuss these mechanisms, and present experimental evidence showing that both can adversely affect cardiac myocytes in vitro, in a way that can contribute to a decline in the overall cardiac function. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1147 / 1161

页数：15

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