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The macrophage in chronic obstructive pulmonary disease

被引：257
作者：
Shapiro, SD
机构：
[1] Washington Univ, St Louis Childrens Hosp, Sch Med, Dept Pediat, St Louis, MO 63110 USA
[2] Washington Univ, St Louis Childrens Hosp, Sch Med, Dept Med, St Louis, MO 63110 USA
[3] Washington Univ, St Louis Childrens Hosp, Sch Med, Dept Cell Biol, St Louis, MO 63110 USA
[4] Washington Univ, St Louis Childrens Hosp, Sch Med, Dept Physiol, St Louis, MO 63110 USA
来源：
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | 1999年 / 160卷 / 05期
关键词：
D O I：
10.1164/ajrccm.160.supplement_1.9
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
Macrophages are the predominant defense cell in the normal lung and during conditions associated with chronic inflammation such as COPD. However, the role of the macrophage in the development of COPD has been controversial. Scientific evidence from a variety of sources is emerging that supports a primary role for the macrophage in regulating the inflammatory response and tissue destruction associated with COPD. The role of macrophage proteinases in the development of emphysema, a major component of COPD, will be discussed.
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收藏
页码：S29 / S32
页数：4
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