PDCD2 is a negative regulator of HCF-1 (C1)

被引：44

作者：

Scarr, RB

Sharp, PA

机构：

[1] MIT, Dept Biol, Ctr Canc Res, Cambridge, MA 02139 USA

[2] MIT, McGovern Inst Brain Res, Cambridge, MA 02139 USA

来源：

ONCOGENE | 2002年 / 21卷 / 34期

关键词：

host cell factor 1 (HCF-1); MYND domain; PDCD2; protein; N-CoR/mSin3A corepressor complexes; cell cycle progression;

D O I：

10.1038/sj.onc.1205647

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Temperature sensitive mutations in host cell factor 1 (HCF-1) arrest cells in the middle of the G1 phase of the cycle. We have shown that the highly conserved C-terminal WYF domain of HCF-1 protein interacts with the MYND domain of the PDCD2 protein. This interaction is conserved between human HCF-1 and HCF-2 and the C. elegans HCF. Overexpression of PDCD2, which interacts with the N-CoR/mSin3A corepressor complexes, suppresses cotransfected HCF-1 complementation of a temperature lesion in the endogenous HCF-1 protein. Overexpression of domains of either PDCD2 or HCF-1, which should interfere with interactions between these two proteins, enhances the complementation.

引用

收藏

页码：5245 / 5254

页数：10

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