Protective effects of a benzoxazine derivative against oxidized LDL-induced apoptosis and the increases of integrin β4, ROS, NF-κB and P53 in human umbilical vein endothelial cells

被引：43

作者：

Liu, Xia ^{[3
,4
,5
]}

Zhao, Jing ^{[3
,4
,5
]}

Xu, JiPing ^{[2
]}

Zhao, BaoXiang ^{[1
]}

Zhang, Yun ^{[4
,5
]}

Zhang, ShangLi ^{[3
,4
,5
]}

Miao, JunYing ^{[3
,4
,5
]}

机构：

[1] Shandong Univ, Sch Chem & Chem Engn, Inst Organ Chem, Jinan 250100, Peoples R China

[2] Shandong Univ, Hosp 2, Dept Neural Med, Jinan 250033, Peoples R China

[3] Shandong Univ, Sch Life Sci, Inst Dev Biol, Jinan 250100, Peoples R China

[4] Shandong Univ, Qilu Hosp, Key Lab Cardiovasc Remodeling & Funct Res, Chinese Minist Educ, Jinan 250012, Peoples R China

[5] Shandong Univ, Qilu Hosp, Key Lab Cardiovasc Remodeling & Funct Res, Chinese Minist Hlth, Jinan 250012, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 10期

基金：

中国国家自然科学基金;

关键词：

6-Amino-2,3-dihydro-3-hydroxymethyl-1,4-benzoxazine; Oxidized low-density lipoprotein; Vascular endothelial cells; Apoptosis; Mechanism; OXIDATIVE STRESS; ACTIVATION; ATHEROSCLEROSIS;

D O I：

10.1016/j.bmcl.2009.03.070

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

To investigate whether 6-amino-2,3-dihydro-3-hydroxymethyl-1,4-benzoxazine (ABO) inhibits oxidized low-density lipoprotein (oxLDL)-induced human umbilical vein endothelial cell (HUVEC) apoptosis, we treated HUVECs with oxLDL in the absence or presence of ABO. The results showed that ABO could act as an effective inhibitor of oxLDL-elicited HUVEC apoptosis by inhibiting the levels of integrin beta 4, reactive oxygen species (ROS), NF-kappa B and P53, and suppressing NF-kappa B nuclear translocation. (C) 2009 Elsevier Ltd. All rights reserved.

引用

收藏

页码：2896 / 2900

页数：5

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