Urocortin

被引：46

作者：

Latchman, DS ^{[1
]}

机构：

[1] UCL, Inst Child Hlth, London WC1N 1EH, England

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2002年 / 34卷 / 08期

关键词：

corticotrophin-releasing hormone; brain; heart; peptide hormone;

D O I：

10.1016/S1357-2725(02)00011-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Urocortin (Ucn) is a 40 amino acid peptide which is closely related to corticotrophin-releasing factor (CRF). It is expressed in specific regions of the brain but is also detectable in other organs notably the heart. Although some of the effects of Ucn in the nervous system such as enhanced anxiety and activity mimic those of CRF, Ucn is a much more potent suppressor of appetite/feeding behaviour. Moreover, Ucn has much more potent effects on the cardiovascular system than CRF, including enhanced cardiac contractility/heart rate and enhanced resistance of cardiac cells to injury induced, for example, by ischaemia/reperfusion. This suggests Ucn may play a key role in the response of the cardiovascular system to stress. In addition, Ucn represents a novel cardioprotective agent which may be of therapeutic use in treating the damaging effects of cardiac ischaemia and subsequent reperfusion. (C) 2002 Elsevier Science Ltd. All rights reserved.

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收藏

页码：907 / 910

页数：4

相关论文

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