RVB1/RVB2: Running Rings around Molecular Biology

被引：187

作者：

Jha, Sudhakar ^{[1
]}

Dutta, Anindya ^{[1
]}

机构：

[1] Univ Virginia, Dept Biochem & Mol Genet, Sch Med, Charlottesville, VA 22908 USA

来源：

MOLECULAR CELL | 2009年 / 34卷 / 05期

关键词：

CHROMATIN-REMODELING COMPLEX; STRAND BREAK REPAIR; HISTONE ACETYLTRANSFERASE COMPLEX; METASTASIS SUPPRESSOR GENE; RUVB-LIKE PROTEIN; DNA-DAMAGE; BETA-CATENIN; BOX-C/D; C-MYC; DOWN-REGULATION;

D O I：

10.1016/j.molcel.2009.05.016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

RVB1/RVB2 (also known as Pontin/Reptin, TIP49/TIP48, RuvbL1/RuvbL2, ECP54/ECP51, INO80H/INO80J, TIH1/TIH2, and TIP49A/TIP49B) are two highly conserved members of the AAA+ family that are present in different protein and nucleoprotein complexes. Recent studies implicate the RVB-containing complexes in many cellular processes such as transcription, DNA damage response, snoRNP assembly, cellular transformation, and cancer metastasis. In this review, we discuss recent advances in our understanding of RVB containing complexes and their role in these pathways.

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页码：521 / 533

页数：13

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